| Lymphatic development in mouse small intestine. | |
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MedLine Citation:
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PMID: 17576138 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lymphatic vessels in the small intestine serve as essential conduits for the absorption and transport of lipids from the intestine to the thoracic duct. Although the morphology and function of the intestinal lymphatic vasculature are well known, little is known about the embryonic development of these vessels. In this study, we examined development of lymphatic and blood vasculatures in the intestinal tube during mouse embryonic development by immunostaining with recently discovered molecular markers for lymphatic endothelial cells: LYVE-1, VEGFR3, Prox-1, and podoplanin. Immature lymphatics became detectable in mesentery, but not in intestinal tube, around E13.5-E14.5, while organized lymphatic vessel plexuses and capillaries were observed in intestinal tube and villi around E17.5. These lymphatic plexuses and capillaries in the intestinal tube appeared to be formed through an active branching process associated with activation of VEGFR3 and involvement of LYVE-1+ macrophages. Our data also reveal that the lymphatic vessels in the intestinal tube, unlike the blood vessels, have not originated from the mesoderm of intestine. All lymphatic vessels in the intestinal tube originated by extension of mesenteric lymphatic vessels through an active branching process. Although the formation of lymphatic vessels follows the formation of blood vessels in the intestine, a mature lymphatic vasculature is formed before birth. Together, our study reveals the temporal and spatial windows of intestinal lymphatic development during embryonic development in mouse. |
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Authors:
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Kyung Eun Kim; Hoon-Ki Sung; Gou Young Koh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Developmental dynamics : an official publication of the American Association of Anatomists Volume: 236 ISSN: 1058-8388 ISO Abbreviation: Dev. Dyn. Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-07-02 Completed Date: 2007-10-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9201927 Medline TA: Dev Dyn Country: United States |
Other Details:
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Languages: eng Pagination: 2020-5 Citation Subset: IM |
Copyright Information:
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Copyright 2007 Wiley-Liss, Inc. |
Affiliation:
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National Research Laboratory of Vascular Biology and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Glycoproteins / metabolism Intestine, Small / cytology, embryology*, metabolism Lymphatic System / cytology, embryology*, metabolism Macrophages Male Mice Mice, Inbred C57BL Specific Pathogen-Free Organisms |
| Chemical | |
Reg. No./Substance:
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0/Glycoproteins; 0/Xlkd1 protein, mouse |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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