| Lymphangioscintigraphy in AIDS-associated Kaposi sarcoma. | |
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MedLine Citation:
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PMID: 2115258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Kaposi sarcoma, a common opportunistic neoplasm complicating AIDS, is thought to arise from the vasculature and possibly from lymphatic endothelium. To evaluate the nature and extent of lymphatic involvement in AIDS-associated Kaposi sarcoma, we used an improved technique of whole-body lymphangioscintigraphy. Six human-immunodeficiency-virus-seropositive men (40-51 years old) with AIDS and extensive Kaposi sarcoma had bilateral foot and/or hand intradermal injection of 0.05 ml of 99mTc-labeled human serum albumin (500 microCi, 18.5 MBq). After sequential whole-body scanning with a digital gamma camera, the findings were interpreted by comparing them with findings from similar studies in 30 other patients without AIDS or Kaposi sarcoma (26 with primary or secondary lymphedema and four with normal extremities). Unlike in normal limbs, where lymphangioscintigraphy displayed early lymphatic truncal and regional nodal filling with radionuclide, in patients with Kaposi sarcoma, lymphangioscintigraphy disclosed a variety of abnormal patterns with some features distinct and others resembling lymphatic dysplasia as seen in primary and secondary lymphedema. These included focal accumulation of tracer within lymphatic channels in the distribution of cutaneous Kaposi lesions; delayed tracer transport with absent, faint, or intense regional lymph nodal uptake; and retarded or impeded lymphatic drainage with tracer intensification in the region of Kaposi sarcoma plaques. The impaired lymphatic drainage and nodal dysfunction seen on scintigrams in patients with AIDS-associated Kaposi sarcoma suggest a close connection between the lymphatic system and this disorder. |
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Authors:
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M H Witte; M Fiala; G C McNeill; C L Witte; W H Williams; J Szabo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: AJR. American journal of roentgenology Volume: 155 ISSN: 0361-803X ISO Abbreviation: AJR Am J Roentgenol Publication Date: 1990 Aug |
Date Detail:
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Created Date: 1990-08-21 Completed Date: 1990-08-21 Revised Date: 2008-02-15 |
Medline Journal Info:
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Nlm Unique ID: 7708173 Medline TA: AJR Am J Roentgenol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 311-5 Citation Subset: AIM; IM; X |
Affiliation:
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Department of Surgery, University of Arizona College of Medicine, Tucson 85724. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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complications*,
radionuclide imaging Adult Extremities HIV Seropositivity Humans Injections, Intradermal Lymphatic System / radionuclide imaging* Male Middle Aged Sarcoma, Kaposi / etiology, radionuclide imaging* Technetium Tc 99m Aggregated Albumin / administration & dosage, diagnostic use* |
| Chemical | |
Reg. No./Substance:
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0/Technetium Tc 99m Aggregated Albumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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