Document Detail

Lymphangiosarcoma in a cat.
MedLine Citation:
PMID:  17706243     Owner:  NLM     Status:  MEDLINE    
This report describes a 5-year-old female cat with lymphangiosarcoma arising within the dermis and subcutis of the caudal mammary region. The mass presented as a large, poorly demarcated and fluctuant swelling with bruising of the overlying skin. Histopathologically, the dermis and subcutis in the affected region were diffusely oedematous, haemorrhagic, and infiltrated by plump spindle cells that formed irregular vascular clefts and cavernous channels. Neoplastic cells were aligned in one or more layers along oedematous collagenous trabeculae. The vascular clefts and channels contained only a few or no erythrocytes. The neoplastic cells had moderate to marked nuclear pleomorphism and prominent nucleoli. Lymphocytes and plasma cells were scattered throughout the neoplasm and the adjacent soft tissues. Immunohistochemical labelling revealed the neoplastic cells to express vimentin, factor VIII-related antigen and the lymphatic endothelial cell marker PROX-1, but the cells did not express cytokeratin. The nuclei of many neoplastic cells expressed the proliferation marker Ki67. These histopathological and immunohistochemical findings confirmed the diagnosis of lymphangiosarcoma. This is the first report describing the usefulness of expression of PROX-1 for differentiating between angiosarcoma of lymphatic and vascular origin in cats.
A Sugiyama; T Takeuchi; T Morita; Y Okamura; S Minami; T Tsuka; T Tabuchi; Y Okamoto
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-08-13
Journal Detail:
Title:  Journal of comparative pathology     Volume:  137     ISSN:  0021-9975     ISO Abbreviation:  J. Comp. Pathol.     Publication Date:    2007 Aug-Oct
Date Detail:
Created Date:  2007-09-07     Completed Date:  2007-11-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0102444     Medline TA:  J Comp Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  174-8     Citation Subset:  IM    
Department of Clinical Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, Japan.
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MeSH Terms
Cat Diseases / diagnosis,  metabolism,  pathology*
Dermis / metabolism,  pathology
Diagnosis, Differential
Homeodomain Proteins / metabolism
Lymphangiosarcoma / metabolism,  pathology,  veterinary*
Mammary Glands, Animal
Skin Neoplasms / metabolism,  pathology,  veterinary*
Tumor Suppressor Proteins / metabolism
Vimentin / metabolism
von Willebrand Factor / metabolism
Reg. No./Substance:
0/Homeodomain Proteins; 0/Tumor Suppressor Proteins; 0/Vimentin; 0/prospero-related homeobox 1 protein; 0/von Willebrand Factor

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