Document Detail

Lymphadenopathy and lymph node infarction as a result of gold injections.
MedLine Citation:
PMID:  11429432     Owner:  NLM     Status:  MEDLINE    
This report describes a case of lymphadenopathy and lymph node infarction as a consequence of intramuscular gold administered to a patient suffering from rheumatoid arthritis, to highlight this rare association. A 34 year old woman with a four year history of rheumatoid arthritis affecting multiple joints was started on intramuscular gold injections after little response to anti-inflammatory medication. After her sixth injection the patient developed enlarged neck and axillary lymph nodes. Biopsy showed subtotal infarction of a reactive node, confirmed by histochemical, immunohistochemical, and molecular techniques. The patient continued to suffer from rheumatoid arthritis with no evidence of malignant lymphoma after three years. This case provides strong evidence that lymphadenopathy with infarction is a rare complication of gold injections. In such a situation, it is particularly important to exclude a diagnosis of lymphoma, because this is the most common cause of spontaneous lymph node infarction. This can be achieved through awareness of the association, and by the use of ancillary histochemical, immunohistochemical, and molecular techniques on the biopsy material.
C Roberts; P J Batstone; J R Goodlad
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  54     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-06-28     Completed Date:  2001-08-02     Revised Date:  2008-11-20    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  562-4     Citation Subset:  AIM; IM    
Department of Pathology, Highland Acute Hospitals NHS Trust, Raigmore Hospital, Inverness, UK.
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MeSH Terms
Antirheumatic Agents / adverse effects*
Arthritis, Rheumatoid / drug therapy
Diagnosis, Differential
Follow-Up Studies
Gold Sodium Thiomalate / adverse effects*
Infarction / chemically induced*,  diagnosis
Lymph Nodes / blood supply*
Lymphoma / diagnosis
Reg. No./Substance:
0/Antirheumatic Agents; 12244-57-4/Gold Sodium Thiomalate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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