| Lymphadenectomy extent is closely related to long-term survival in esophageal cancer. | |
| | |
MedLine Citation:
|
PMID: 17145185 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The optimal extent of lymphadenectomy during esophagectomy for esophageal cancer remains debatable. The aim of this study was to identify the effect of the extent of lymphadenectomy on survival and recurrence after esophagectomy in esophageal cancer. MATERIALS AND METHODS: Two hundred thirty-three patients who were operated on between January 1995 and December 2003 due to esophageal cancer were included. The study subjects were stage I, II, and III esophageal squamous cell carcinoma patients who had undergone curative resection without neoadjuvant chemotherapy or chemoradiation therapy. To analyze the extent of lymphadenectomy, lymph node stations were classified into three regions, namely, paraesophageal, upper thoracic, and abdominal regions, and patients were allocated to one of three groups, i.e., group 1 received lymphadenectomy in one region only, group 2 in two regions, and group 3 in three regions. RESULTS: The pathologic stages were stage I in 57 (24.5%), IIA in 69 (29.6%), IIB in 27 (11.6%), and III in 80 (34.3%). There were 67 patients in group 1, 102 in group 2, and 64 in group 3. The operative mortality rate was 2.1%. Postoperative morbidity rates and hospital stay periods were no different for the three groups. The overall 5-year survivals in groups 1, 2, and 3 were 21.2, 36.3, and 53.7%, respectively, and there were statistically significant differences between groups (p=0.019). Overall 5-year survival for those with N0 disease was different significantly in the groups (26.7, 56.8, and 74.4% in groups 1, 2, and 3, respectively; p=0.001). However, overall 5-year survival differences for N1 disease were not significant. Group 1 showed more frequent locoregional recurrence than groups 2 and 3 (34.3 vs 12.7% and 15.6%, p=0.002). However, distant recurrence was no different in the three groups. CONCLUSIONS: A wider extent of lymphadenectomy in esophageal cancer was associated with better long-term survival than limited lymphadenectomy, especially in N0 patients. In addition, increased survival was found to be inversely associated with locoregional recurrence. |
| | |
Authors:
|
Chang Hyun Kang; Young Tae Kim; Sang-Hoon Jeon; Sook-Whan Sung; Joo Hyun Kim |
Related Documents
:
|
12174925 - A fractal dimension analysis: a new method for evaluating the response of anticancer th... 18028955 - Prognostic significance of lymph node metastases and ratio in esophageal cancer. 9735235 - Apoptosis in esophageal cancer following induction chemoradiotherapy. 19730945 - Prognostic significance of endoluminal ultrasound-defined disease length and tumor volu... 17960795 - Survival improvements for advanced stage nonbronchioloalveolar carcinoma-type nonsmall ... 19362785 - Is radiotherapy a good adjuvant strategy for men with a history of cryptorchism and sta... |
Publication Detail:
|
Type: Journal Article Date: 2006-12-04 |
Journal Detail:
|
Title: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery Volume: 31 ISSN: 1010-7940 ISO Abbreviation: Eur J Cardiothorac Surg Publication Date: 2007 Feb |
Date Detail:
|
Created Date: 2007-01-30 Completed Date: 2007-04-16 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8804069 Medline TA: Eur J Cardiothorac Surg Country: Germany |
Other Details:
|
Languages: eng Pagination: 154-60 Citation Subset: IM |
Affiliation:
|
Department of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University Hospital, Clinical Research Institute, Seoul National University College of Medicine, Seoul, South Korea. chkang@snu.ac.kr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Carcinoma, Squamous Cell / pathology, secondary*, surgery* Epidemiologic Methods Esophageal Neoplasms / pathology, surgery* Esophagectomy Female Humans Lymph Node Excision / methods* Lymphatic Metastasis Male Middle Aged Neoplasm Staging Recurrence |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Influence of inlet positions on the flow behavior inside a photoreactor using radiotracers and color...
Next Document: The "SCG10-LIke Protein" SCLIP is a novel regulator of axonal branching in hippocampal neu...