| Lymph node metastasis diagnosis using positron emission tomography with 2-[18F] fluoro-2-deoxy-D-glucose as a tracer and computed tomography in surgical cases of non-small cell lung cancer. | |
| | |
MedLine Citation:
|
PMID: 22290887 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVESPositron emission tomography with 2-[(18)F] fluoro-2-deoxy-d-glucose as a tracer and computed tomography (FDG-PET/CT) are utilized for the diagnosis of lymph node (LN) metastasis from lung cancer. In this study, we analyzed the diagnostic ability of FDG-PET for N staging by focusing on the clinical features of false-positive (FP) and false-negative (FN) cases.METHODSFrom March 2006 to February 2010, 112 patients underwent preoperative examinations using FDG-PET/CT followed by radical resection with hilar and mediastinal dissection. We analyzed their clinicopathological characteristics based on preoperative FDG-PET/CT findings and post-operative histopathological diagnosis of resected LNs.RESULTSBased on the PET/CT results, 17 patients were misdiagnosed (9 FN and 8 FP). The sensitivity, specificity, accuracy and negative and positive predictive values for N1/N2 were 50.0, 94.5, 84.0, 93.0 and 58.3%, respectively, whereas those for N2 were 57.8, 90.3, 84.8, 90.3 and 61.1%, respectively. FP findings more frequently occurred in cases with elevated white blood cell (WBC) count (P = 0.015) and smokers (P = 0.04). In the FN group, the maximum standardized uptake value for the primary tumour was lower than that in the true-positive (TP) group (P = 0.01). The short-axis sizes of 71 LNs differently diagnosed by PET/CT and histopathology findings were significantly smaller in the FN group than the TP group (P < 0.001), whereas there was no difference between TP and FP. As for FN LNs in the TP group, there was no significant difference.CONCLUSIONSPET/CT showed a good ability to detect metastatic LNs, especially for N2 diagnosis. However, there were some limitations, especially in cases with elevated peripheral WBC count and/or smoking history. |
| | |
Authors:
|
Naoko Ose; Noriyoshi Sawabata; Masato Minami; Masayoshi Inoue; Yasushi Shintani; Yoshihisa Kadota; Meinoshin Okumura |
Related Documents
:
|
11956717 - Abdominal compartment syndrome in children: ct findings. 22014607 - Widespread cerebral cortical mineralization in wilson's disease detected by susceptibil... 22280807 - Fdg-pet-ct reduces the interobserver variability in rectal tumor delineation. 16479657 - Ct of the acute (emergency) abdomen. 2166047 - Neomycin and omega-conotoxin gvia interact at a common neuronal site in peripheral tiss... 10344507 - Mri of acute cerebral infarcts, increased contrast enhancement with continuous infusion... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-18 |
Journal Detail:
|
Title: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery Volume: - ISSN: 1873-734X ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8804069 Medline TA: Eur J Cardiothorac Surg Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cumulative radiation exposure during thoracic endovascular aneurysm repair and subsequent follow-up.
Next Document: Modern management of systolic anterior motion of the mitral valve.