Document Detail

Lymph node harvesting in colorectal carcinoma specimens.
MedLine Citation:
PMID:  21528668     Owner:  NLM     Status:  In-Process    
INTRODUCTION: Adequate lymph node evaluation is an important determinant of prognosis in patients with colorectal cancer. Current guidelines recommend evaluation of at least 12 lymph nodes; however, a significant number of patients fail to meet these criteria.
AIM: To investigate the factors that influence adequate recovery and evaluation of lymph nodes in colorectal cancer.
METHODS: We retrospectively analyzed 454 consecutive cases of colorectal cancer surgically treated from September 2000 to September 2006. Univariate and multivariate linear and logistic regression analysis was used to study the effect of various factors in lymph node recovery.
RESULTS: The number of lymph nodes retrieved ranged from 0 to 62 with a median of 13 nodes. Overall, 189 (41.6%) patients had fewer than 12 nodes removed. Patient age, tumor stage, location and size were associated with lymph node retrieval. Multivariable regression revealed that the aforementioned variables, including gender and hospital type, explained 17% of the observed variance of the lymph node number.
CONCLUSION: Patient and tumor characteristics, although important, are only partly responsible for the variation of lymph node yield. Quality of surgical resection and/or the thoroughness of examination of the tissue by the pathologist might explain the wider proportion of this variance. Training in colorectal node evaluation could help to improve the quality of cancer care.
Emmanuel Lagoudianakis; Apostolos Pappas; Nikolaos Koronakis; Dimitrios Tsekouras; John Dallianoudis; Panagiota Kontogianni; Dimitrios Papanikolaou; John Chrysikos; George Karavitis; Haridimos Markogiannakis; Konstantinos Filis; Andreas Manouras
Related Documents :
1748228 - Treatment with biologic response modifiers in patients with ovarian cancer.
15725958 - Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome associated with high-dose...
21246528 - Histology predicts a favorable outcome in young children with desmoplastic medulloblast...
21557838 - Focal therapy with high-intensity focused ultrasound for prostate cancer in the elderly...
24705888 - Survival improvement of poor-prognosis aml/mds patients by maintenance treatment with l...
9429328 - Cancer of the penis--a review of 50 patients.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tumori     Volume:  97     ISSN:  0300-8916     ISO Abbreviation:  Tumori     Publication Date:    2011 Jan-Feb
Date Detail:
Created Date:  2011-05-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0111356     Medline TA:  Tumori     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  74-8     Citation Subset:  IM    
First Department of Propaedeutic Surgery, Hippokrateion Hospital, Athens Medical School, University of Athens, Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Surgical therapy of vertebral metastases. Are there predictive parameters for intraoperative excessi...
Next Document:  Prognostic significance of p53 protein and X-ray repair cross-complementing protein 1 in non-small c...