Document Detail


Lymph node dissection--understanding the immunological function of lymph nodes.
MedLine Citation:
PMID:  22861359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lymph nodes (LN) are one of the important sites in the body where immune responses to pathogenic antigens are initiated. This immunological function induced by cells within the LN is an extensive area of research. To clarify the general function of LN, to identify cell populations within the lymphatic system and to describe the regeneration of the lymph vessels, the experimental surgical technique of LN dissection has been established in various animal models. In this review different research areas in which LN dissection is used as an experimental tool will be highlighted. These include regeneration studies, immunological analysis and studies with clinical questions. LN were dissected in order to analyse the different cell subsets of the incoming lymph in detail. Furthermore, LN were identified as the place where the induction of an antigen-specific response occurs and, more significantly, where this immune response is regulated. During bacterial infection LN, as a filter of the lymph system, play a life-saving role. In addition, LN are essential for the induction of tolerance against harmless antigens, because tolerance could not be induced in LN-resected animals. Thus, the technique of LN dissection is an excellent and simple method to identify the important role of LN in immune responses, tolerance and infection.
Authors:
M Buettner; U Bode
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  169     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-06     Completed Date:  2012-10-16     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  205-12     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Clinical and Experimental Immunology © 2012 British Society for Immunology.
Affiliation:
Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany. buettner.manuela@mh-hannover.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Movement
Coloring Agents / pharmacokinetics
Dissection / methods
Forecasting
Immune Tolerance
Immunity, Innate
Infection / immunology
Lymph / immunology
Lymph Node Excision / methods*
Lymph Nodes / immunology*,  ultrastructure
Lymphatic System / anatomy & histology,  physiology
Lymphatic Vessels / physiology
Lymphocyte Subsets / immunology
Mesentery / immunology
Mice
Mice, Knockout
Models, Immunological
Regeneration / physiology
Chemical
Reg. No./Substance:
0/Coloring Agents
Comments/Corrections

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