Document Detail

Lymph node detection of head and neck squamous cell carcinomas by positron emission tomography with fluorodeoxyglucose F 18 in a routine clinical setting.
MedLine Citation:
PMID:  10604409     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Accurate determination of lymph node involvement is a prerequisite for individualized therapy in patients with squamous cell carcinoma of the head and neck region. In a previous study, we showed that positron emission tomography (PET) with fluorodeoxyglucose F 18 with and without attenuation correction is superior to magnetic resonance imaging for this purpose in a scientific setting. OBJECTIVE: To evaluate the diagnostic accuracy of a shortened PET protocol (acquisition time, 20 minutes) in a routine clinical setting. DESIGN: The results of static, nonattenuation-corrected PET performed on patients in 2 bed positions starting 40 minutes after the intravenous injection of 370 MBq of fluorodeoxyglucose F 18 and the results of morphologic procedures (computed tomography and magnetic resonance imaging) were compared prospectively in 70 patients for lymph node staging. Postoperative pathologic findings served as a criterion standard. SETTING: An academic medical center. RESULTS: The diagnostic accuracy of PET for detecting "neck sides" with malignant involvement was superior to morphologic procedures, with a sensitivity and specificity of 87% and 94%, respectively, compared with computed tomographic values of 65% and 47% and magnetic resonance imaging values of 88% and 41%, respectively. CONCLUSION: A short PET protocol that is suitable for routine clinical use is superior to morphologic procedures (computed tomography and magnetic resonance imaging) for the detection of lymph node involvement in head and neck squamous cell carcinomas.
R J Kau; C Alexiou; C Laubenbacher; M Werner; M Schwaiger; W Arnold
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of otolaryngology--head & neck surgery     Volume:  125     ISSN:  0886-4470     ISO Abbreviation:  Arch. Otolaryngol. Head Neck Surg.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-01-05     Completed Date:  2000-01-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8603209     Medline TA:  Arch Otolaryngol Head Neck Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1322-8     Citation Subset:  AIM; IM    
Department of Otorhinolaryngology-Head and Neck Surgery, Technical University of Munich, Germany.
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MeSH Terms
Academic Medical Centers
Carcinoma, Squamous Cell / pathology*,  surgery
Combined Modality Therapy
Fluorodeoxyglucose F18 / diagnostic use*
Head and Neck Neoplasms / pathology*,  surgery
Lymph Node Excision
Lymph Nodes / pathology*,  radionuclide imaging*
Magnetic Resonance Imaging
Middle Aged
Neck / pathology,  radionuclide imaging
Sensitivity and Specificity
Tomography, Emission-Computed / methods*
Tomography, X-Ray Computed
Reg. No./Substance:
63503-12-8/Fluorodeoxyglucose F18

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