Document Detail


Lymph node biopsy in the diagnostic and prognostic assessment of patients with HIV infection.
MedLine Citation:
PMID:  2807838     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thirty-three anti-HIV positive patients with persistent generalized lymphadenopathy (PGL) who underwent lymph-node biopsy were studied to assess the diagnostic and prognostic relations existing between clinical, histological and laboratory findings. Patients were also examined for known risk factors, laboratory and bacteriological tests, and mononuclear cell surface marker analysis. 4 histological types were identified according to Ràcz's classification. At biopsy, there were 21 cases of LAS (64%), 6 cases of ARC (18%) and 6 cases of AIDS (18%); a clear prevalence of type 1 was evidenced in LAS/ARC patients, while only type 4 was present in the AIDS group. An ARC type 3 patient developed manifest AIDS within 13 months from biopsy. These results suggest that anti-HIV positive asymptomatic patients with PGL apparently do not require lymph node biopsy, as none of them showed histologic findings suggestive of opportunistic infections, malignant lymphoma or Kaposi's sarcoma. On the contrary, lymph node biopsy can play a diagnostic and prognostic role in anti-HIV negative subjects with PGL, and in ARC and AIDS patients.
Authors:
F Badellino; L Moresco; M Gipponi; F Cafiero; A Perasole; G Pagano; A Alessandrini; G Nicolò
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Italian journal of surgical sciences / sponsored by Società italiana di chirurgia     Volume:  19     ISSN:  0392-3525     ISO Abbreviation:  Ital J Surg Sci     Publication Date:  1989  
Date Detail:
Created Date:  1989-12-05     Completed Date:  1989-12-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8213451     Medline TA:  Ital J Surg Sci     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  217-24     Citation Subset:  IM; X    
Affiliation:
Divisione di Oncologia Chirurgica, Istituto Nazionale per la Ricerca sul Cancro, Genova.
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MeSH Terms
Descriptor/Qualifier:
AIDS-Related Complex / pathology*
Acquired Immunodeficiency Syndrome / pathology
Adolescent
Adult
Biopsy
Child
Child, Preschool
Female
Follow-Up Studies
HIV Infections / pathology*
Humans
Lymph Nodes / pathology*
Male
Prognosis
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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