Document Detail

Lymph isolated from a regional scald injury produces a negative inotropic effect in dogs.
MedLine Citation:
PMID:  9710726     Owner:  NLM     Status:  MEDLINE    
Large surface-area burns in patients have been associated with a severe impairment in cardiac performance, as evidenced by a decline in cardiac output. The mechanisms responsible for this profound myocardial dysfunction are largely unknown. We investigated the effects of lymph isolated from the scalded hind limb of dogs on regional myocardial blood flow, coronary vascular reactivity, and contractile performance. Dogs were instrumented with ultrasonic dimension crystals in the myocardium supplied by the left anterior descending (LAD) and by the left circumflex (LCx) coronary arteries. After cannulating a hind limb lymphatic, lymph was infused directly into the LAD before and after a 10-second 100 degrees C hind limb scald. Scalding alone did not alter myocardial contractile performance in the LAD or LCx regions, coronary artery blood flow, or systemic hemodynamics. Interestingly, postburn lymph infused into the LAD resulted in a 38% decline in LAD zone segment shortening (p < 0.01 vs baseline) that lasted throughout the 5-hour observation period. In contrast, segment shortening in the (control) LCx region was unaffected by postburn lymph injections into the LAD. Regional myocardial blood flow (radiolabeled microspheres) in the LAD and LCx regions was unchanged after scald injury or intracoronary injection of postburn lymph. In addition, LAD coronary artery vascular reactivity to acetylcholine and nitroglycerin was also unaffected by the regional thermal injury or by injection of lymph into the LAD. These data suggest that a regional scald injury results in the production and release of a potent myocardial depressant factor(s) that produces a direct negative inotropic effect on the canine myocardium.
J J Ferrara; E W Franklin; E L Kukuy; D M Flynn; D A Gilman; V A Keller; E U Choe; L M Flint; D J Lefer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of burn care & rehabilitation     Volume:  19     ISSN:  0273-8481     ISO Abbreviation:  J Burn Care Rehabil     Publication Date:    1998 Jul-Aug
Date Detail:
Created Date:  1998-10-19     Completed Date:  1998-10-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8110188     Medline TA:  J Burn Care Rehabil     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  296-304     Citation Subset:  IM    
Department of Surgery, Tulane University School of Medicine, New Orleans, LA 70112, USA.
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MeSH Terms
Burns / metabolism*
Coronary Vessels / drug effects*
Hemodynamics / drug effects
Lymph / chemistry*
Myocardial Contraction / drug effects*
Time Factors
Vasomotor System / drug effects

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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