| Lymph circulation in the liver. | |
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MedLine Citation:
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PMID: 18484610 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The liver produces a large amount of lymph, which is estimated to be 25 to 50 % of lymph flowing through the thoracic duct. The hepatic lymphatic system falls into three categories depending on their locations: portal, sublobular, and superficial lymphatic vessels. It is suggested that 80 % or more of hepatic lymph drains into portal lymphatic vessels, while the remainder drains through sublobular and capsular lymphatic vessels. The hepatic lymph primarily comes from the hepatic sinusoids. Our tracer studies, together with electron microscopy, show many channels with collagen fibers traversing through the limiting plate and connecting the space of Disse with the interstitial space either in the portal tracts, or around the sublobular veins. Fluid filtered out of the sinusoids into the space of Disse flows through the channels traversing the limiting plate either independently of blood vessels or along blood vessels and enters the interstitial space of either portal tract or sublobular veins. Fluid in the space of Disse also flows through similar channels traversing the hepatocytes intervening between the space of Disse and the hepatic capsule and drains into the interstitial space of the capsule. Fluid and migrating cells in the interstitial space pass through prelymphatic vessels to finally enter the lymphatic vessels. The area of the portal lymphatic vessels increases in liver fibrosis and cirrhosis and in idiopathic portal hypertension. Lymphatic vessels are abundant in the immediate vicinity of the hepatocellular carcinoma (HCC) and liver metastasis. HCCs expressing vascular endothelial growth factor-C are more liable to metastasize, indicating that lymphangiogenesis is associated with their enhanced metastasis. |
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Authors:
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Osamu Ohtani; Yuko Ohtani |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Anatomical record (Hoboken, N.J. : 2007) Volume: 291 ISSN: 1932-8494 ISO Abbreviation: Anat Rec (Hoboken) Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-22 Completed Date: 2008-06-27 Revised Date: 2009-12-16 |
Medline Journal Info:
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Nlm Unique ID: 101292775 Medline TA: Anat Rec (Hoboken) Country: United States |
Other Details:
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Languages: eng Pagination: 643-52 Citation Subset: IM |
Affiliation:
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Department of Anatomy, Faculty of Medicine and Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan. osmotani@med.u-toyama.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Cells / physiology Blood Vessels / anatomy & histology, physiology Cell Movement Corrosion Casting Humans Liver / anatomy & histology*, blood supply, physiology* Liver Diseases / pathology Lymph / physiology* Lymphatic Vessels / anatomy & histology*, physiology* Microscopy, Electron, Scanning Microscopy, Electron, Transmission Rabbits Rats |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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