Document Detail

Lyme disease during pregnancy.
MedLine Citation:
PMID:  2423719     Owner:  NLM     Status:  MEDLINE    
Lyme disease is an increasingly recognized tick-borne illness caused by a spirochete, Borrelia burgdorferi. Because the etiologic agent of Lyme disease is a spirochete, there has been concern about the effect of maternal Lyme disease on pregnancy outcome. We reviewed cases of Lyme disease in pregnant women who were identified before knowledge of the pregnancy outcomes. Nineteen cases were identified with onset between 1976 and 1984. Eight of the women were affected during the first trimester, seven during the second trimester, and two during the third trimester; in two, the trimester of onset was unknown. Thirteen received appropriate antibiotic therapy for Lyme disease. Of the 19 pregnancies, five had adverse outcomes, including syndactyly, cortical blindness, intrauterine fetal death, prematurity, and rash in the newborn. Adverse outcomes occurred in cases with infection during each of the trimesters. Although B burgdorferi could not be implicated directly in any of the adverse outcomes, the frequency of such outcomes warrants further surveillance and studies of pregnant women with Lyme disease.
L E Markowitz; A C Steere; J L Benach; J D Slade; C V Broome
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  JAMA     Volume:  255     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-07-09     Completed Date:  1986-07-09     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3394-6     Citation Subset:  AIM; IM    
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MeSH Terms
Blindness / congenital
Dermatitis / congenital
Developmental Disabilities / etiology
Fetal Death / etiology
Infant, Newborn
Infant, Premature
Lyme Disease* / drug therapy
Penicillins / therapeutic use
Pregnancy Complications, Infectious* / drug therapy
Pregnancy Trimester, First
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Syndactyly / etiology
Reg. No./Substance:

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