Document Detail

Lycopene is more bioavailable from tomato paste than from fresh tomatoes.
MedLine Citation:
PMID:  9209178     Owner:  NLM     Status:  MEDLINE    
Lycopene bioavailability from a single dose of fresh tomatoes or tomato paste (23 mg lycopene) ingested together with 15 g corn oil was compared by analyzing carotenoid concentrations in the chylomicron fraction. The lycopene isomer pattern was the same in both fresh tomatoes and tomato paste. The triacylglycerol response in chylomicrons was not significantly different after both treatments. Ingestion of tomato paste was found to yield 2.5-fold higher total and all-trans-lycopene peak concentrations (P < 0.05 and P < 0.005, respectively) and 3.8-fold higher area under the curve (AUC) responses (P < 0.001) than ingestion of fresh tomatoes. The same was calculated for lycopene cis-isomers, but only the AUC response for the cis-isomers was significantly higher after ingestion of tomato paste (P < 0.005). No difference was observed in the alpha- and beta-carotene response. Thus, in humans, the bioavailability of lycopene is greater from tomato paste than from fresh tomatoes.
C Gärtner; W Stahl; H Sies
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  66     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-07-31     Completed Date:  1997-07-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  116-22     Citation Subset:  AIM; IM    
Institut für Physiologische Chemie I, Heinrich-Heine-Universität Düsseldorf, Germany.
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MeSH Terms
Anticarcinogenic Agents / administration & dosage,  pharmacokinetics*
Area Under Curve
Biological Availability
Carotenoids / administration & dosage,  blood,  pharmacokinetics*
Chromatography, High Pressure Liquid
Chylomicrons / metabolism
Lycopersicon esculentum*
Reg. No./Substance:
0/Anticarcinogenic Agents; 0/Chylomicrons; 36-88-4/Carotenoids; 502-65-8/lycopene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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