Document Detail

Ly 1+2- suppressor T cells down-regulate the generation of Ly 1-2+ effector T cells during progressive growth of the P815 mastocytoma.
MedLine Citation:
PMID:  3156088     Owner:  NLM     Status:  MEDLINE    
It has been shown that progressive growth of the P815 mastocytoma in its semisyngeneic B6D2 host results, between days 6 and 9 of tumour growth, in the generation of Ly 1-2+ T cells which are capable, on passive transfer, of causing the regression of an established tumour in gamma-irradiated recipients, and of T cells which are capable of lysing P815 tumour cells in vitro. After 9 days of tumour growth, these effector T cells are progressively lost; this is associated with the progressive acquisition of Ly 1+2- suppressor T cells which are capable of inhibiting the expression of passively transferred immunity against an established tumour in T-cell deficient recipients. The results are consistent with the hypothesis that this P815 mastocytoma grows progressively, in spite of its immunogenicity, because it evokes the generation of suppressor T cells before enough effector T cells are generated to reject it.
R J North; E S Dye
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Immunology     Volume:  54     ISSN:  0019-2805     ISO Abbreviation:  Immunology     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-03-28     Completed Date:  1985-03-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0374672     Medline TA:  Immunology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  47-56     Citation Subset:  IM    
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MeSH Terms
Antigens, Ly / immunology*
Cell Division
Immunization, Passive
Mast-Cell Sarcoma / immunology*,  pathology
Skin Neoplasms / immunology
T-Lymphocytes, Cytotoxic / immunology*
T-Lymphocytes, Regulatory / immunology*
Grant Support
Reg. No./Substance:
0/Antigens, Ly

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