Document Detail


Luteolytic effect of azastene in the nonhuman primate.
MedLine Citation:
PMID:  7078876     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability to block steroidogenesis with 4,4,17-alpha-trimethylandrost-5-eno[2,3,-d]isoxazol-17-ol (azastene) was studied in 3 different models. Oral administration of 500 mg to rhesus monkeys on different days of their luteal phase induced marked depression of circulating progesterone concentrations, and in some cases early onset of menses. Simultaneous administration of human chorionic gonadotropin (hCG) during the midluteal phase did not overcome the luteolytic effect of azastene. Concentrations of 50 micrograms/ml of azastene inhibited testosterone secretion by decapsulated mice testes in vitro in response to hCG [controls, 1165 +/- 196 ng/ml, azastene, 306 +/- 40 ng/ml (P less than .01)]. Production of progesterone by dispersed luteal cells from rhesus monkey corpora lutea was markedly inhibited by the presence of 25 and 50 micrograms/ml azastene in the incubation media (P less than .05 and less than .01, respectively). The availability of a compound that blocks in vivo and in vitro gonadal steroidogenesis opens a new approach to postcoital contraception in primates because of its luteolytic and interceptive activity. The possible mechanisms of action of azastene are discussed.
Authors:
R H Asch; C G Smith; T M Siler-Khodr; A Bartke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  59     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1982 Mar 
Date Detail:
Created Date:  1982-07-22     Completed Date:  1982-07-22     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  303-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Abortifacient Agents / pharmacology*
Abortifacient Agents, Steroidal / pharmacology*
Androstenols / pharmacology*
Animals
Chorionic Gonadotropin / pharmacology
Corpus Luteum / drug effects*
Female
Luteal Phase / drug effects
Luteinizing Hormone / blood
Macaca / physiology*
Macaca mulatta / physiology*
Male
Mice
Progesterone / blood
Testosterone / secretion
Grant Support
ID/Acronym/Agency:
5P30 HD10202/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Abortifacient Agents; 0/Abortifacient Agents, Steroidal; 0/Androstenols; 0/Chorionic Gonadotropin; 13074-00-5/azastene; 57-83-0/Progesterone; 58-22-0/Testosterone; 9002-67-9/Luteinizing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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