| Luteinized unruptured follicle syndrome: incidence and recurrence rate in infertile women with unexplained infertility undergoing intrauterine insemination. | |
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MedLine Citation:
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PMID: 16613885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The objective of this study was to determine the incidence and recurrence rate of luteinized unruptured follicle (LUF) syndrome in women with unexplained infertility undergoing intrauterine insemination (IUI). METHODS: A total of 167 women with unexplained infertility who underwent 292 cycles of IUI were enrolled in the study. All patients were treated with clomiphene citrate, 50-150 mg/daily from day 5 to 9 of their menstrual cycle. Ultrasound examination to confirm ovulation was performed on the day of IUI (day 0) and every day thereafter for another 3 days (days 1, 2 and 3). A total of 69 women who failed to conceive in the first cycle and 56 women who failed to conceive in the second cycle underwent second and third cycles, respectively. RESULTS: Of the total 167 patients who underwent first cycle, 42 (25%) had LUF. The incidence of LUF was 56.5% in 69 patients who underwent a second cycle of IUI treatment, of whom 33 patients had LUF in the first cycle with recurrence rate of 78.6%. In 56 patients who underwent 3 consecutive cycles, the incidence of LUF was 58.9% and recurrence rate of 90%. No pregnancies were recorded in patients with LUF during the study period. CONCLUSION: The incidence and recurrence rate of LUF are significantly increased in subsequent cycles of IUI. In these patients, other options of infertility treatment might be justified. |
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Authors:
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H Qublan; Z Amarin; M Nawasreh; F Diab; S Malkawi; N Al-Ahmad; M Balawneh |
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Publication Detail:
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Type: Journal Article Date: 2006-04-13 |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 21 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-04 Completed Date: 2006-09-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
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Languages: eng Pagination: 2110-3 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, Prince Rashid Hospital, Royal Medical Services, Irbid, Jordan. hqublan@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Clomiphene / therapeutic use Corpus Luteum / pathology Female Humans Incidence Infertility, Female / etiology* Insemination, Artificial / methods Jordan / epidemiology Ovarian Diseases / complications*, epidemiology, pathology Ovarian Follicle / pathology*, ultrasonography Prospective Studies Recurrence Uterus |
| Chemical | |
Reg. No./Substance:
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911-45-5/Clomiphene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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