Document Detail

Luteal phase support in in vitro fertilization: meta-analysis of randomized trials.
MedLine Citation:
PMID:  15785074     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine if luteal phase support improves the pregnancy rate in in vitro fertilization (IVF) cycles. DESIGN: A meta-analysis of randomized trials of luteal phase support was carried out with the main outcome measure being the pregnancy rate per cycle. RESULTS: Fifty-nine trials were evaluated. Eighteen trials met the inclusion criteria. Five main themes were identified: human chorionic gonadotropin (hCG) versus progesterone; progesterone versus progesterone and hCG; progesterone versus placebo; hCG versus placebo, and hCG versus progesterone versus no support. CONCLUSION: Luteal phase support is definitely indicated in IVF treatment cycles. This meta-analysis favored hCG above progesterone as luteal phase support with respect to pregnancy rates. Further prospective randomized trials are needed to determine a definite consensus with respect to the duration of luteal phase support in IVF cycles.
Saleema Nosarka; Thinus Kruger; Igno Siebert; Debbie Grové
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Publication Detail:
Type:  Journal Article; Meta-Analysis     Date:  2005-03-23
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  60     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  2005  
Date Detail:
Created Date:  2005-08-11     Completed Date:  2005-11-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  67-74     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2005 S. Karger AG, Basel.
Department of Obstetrics and Gynaecology, Stellenbosch University, Tygerberg, South Africa.
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MeSH Terms
Chorionic Gonadotropin / pharmacology*
Corpus Luteum Maintenance / drug effects*,  metabolism
Fertilization in Vitro / methods*
Pregnancy Rate
Progesterone / pharmacology*
Randomized Controlled Trials as Topic
Reg. No./Substance:
0/Chorionic Gonadotropin; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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