Document Detail

Luteal function following ovarian stimulation in rhesus monkeys for in vitro fertilization: atypical response to human chorionic gonadotropin treatment simulating early pregnancy.
MedLine Citation:
PMID:  3131158     Owner:  NLM     Status:  MEDLINE    
This study determined if corpora lutea of hyperstimulated cycles in rhesus monkeys could be "rescued" by the pregnancy signal, chorionic gonadotropin (CG), given at the typical time of implantation. At menses, female monkeys received human follicle-stimulating hormone (hFSH, 60 IU, days 1 to 6) followed by human menopausal gonadotropin (hMG, 60 IU hFSH/60 IU luteinizing hormone [hLH], days 7 to 9). On day 10, human chorionic gonadotropin (hCG) was given to mimic the LH surge. Nine days later, a regimen of daily increasing doses of hCG (15 to 360 IU twice a day) was initiated to simulate rescue of the corpus luteum in early pregnancy. Serum levels of progesterone (P) increased through day 5 of the luteal phase but then declined. Circulating levels of bioactive LH were significantly less on days 7 to 9 of the luteal phase than at this stage in the natural cycle. The hCG regimen extended (P less than 0.05) the luteal phase in five of six animals. The hCG treatment elicited a persistent increase (P less than 0.05) in circulating P levels, rather than a transient rise typical of normal or simulated pregnancy in natural cycles. The authors conclude that (1) corpora lutea of hyperstimulated cycles can respond to CG, but (2) there are differences in luteal function during both the luteal phase and simulated early pregnancy that may be due to inadequate luteal development or the abnormal gonadotropin milieu existing after ovulation or both.
C A VandeVoort; D L Hess; R L Stouffer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Fertility and sterility     Volume:  49     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-07-07     Completed Date:  1988-07-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1071-5     Citation Subset:  IM    
Division of Reproductive Biology and Behavior, Oregon Regional Primate Research Center, Beaverton.
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MeSH Terms
Chorionic Gonadotropin / pharmacology*
Corpus Luteum / drug effects
Estradiol / blood
Fertilization in Vitro*
Follicle Stimulating Hormone / pharmacology
Luteal Phase / drug effects*
Luteinizing Hormone / blood
Macaca / physiology*
Macaca mulatta / physiology*
Menotropins / pharmacology
Ovary / drug effects*
Pregnancy, Animal / drug effects*
Progesterone / blood
Time Factors
Grant Support
Reg. No./Substance:
0/Chorionic Gonadotropin; 50-28-2/Estradiol; 57-83-0/Progesterone; 61489-71-2/Menotropins; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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