Document Detail

Luteal contraception.
MedLine Citation:
PMID:  3281964     Owner:  NLM     Status:  MEDLINE    
Progesterone is an important and unique reproductive hormone. It is the main product of the corpus luteum, dominant in the luteal phase of the cycle, and in pregnancy its secretion continues and increases ensuring maintenance of the early conceptus. At any time in these events, the suspension of progesterone action may interfere with successful reproduction. The term 'luteal contraception' was deliberately chosen for the antifertility effect achieved by the elimination of progesterone action through the use of antiprogesterones in the post-ovulatory phase of the cycle, including early pregnancy. Published clinical experience with RU 486 (Mifepristone) as a post-coital contraceptive, implantation inhibitor, once-a-month pill, menstruation regulator and early abortifacient is reviewed. The potentials and limitations of these uses are discussed and the state of art of 'contragestion' by antiprogestagen treatment summarized.
L Kovács
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  3     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-05-26     Completed Date:  1988-05-26     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  169-71     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, University Medical School of Szeged, Hungary.
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MeSH Terms
Contraceptives, Oral, Synthetic*
Contraceptives, Postcoital
Estrenes / pharmacology*
Luteal Phase
Progesterone / antagonists & inhibitors
Reg. No./Substance:
0/Contraceptives, Oral, Synthetic; 0/Contraceptives, Postcoital; 0/Estrenes; 57-83-0/Progesterone; 84371-65-3/Mifepristone

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