| The LupusQoL and associations with demographics and clinical measurements in patients with systemic lupus erythematosus. | |
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MedLine Citation:
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PMID: 20810500 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Having developed and validated a disease-specific health-related quality of life (HRQOL) measure for patients with systemic lupus erythematosus (SLE), the LupusQoL, we determined its relationship to demographic and clinical measurements in a group of patients with SLE. METHODS: A group of 322 outpatients completed the LupusQoL. Demographic (age, sex, marital status, ethnicity) and clinical variables (disease duration, disease activity, damage) were recorded. Associations between the 8 LupusQoL domains and age, disease duration, disease activity, and damage were explored using Spearman's correlation coefficients. Differences in LupusQoL scores were examined for sex and marital status using the Mann-Whitney U test. Ethnic groups were compared using ANOVA. RESULTS: All domains of LupusQoL were impaired, with fatigue (56.3) being the worst affected and body image (80.0) the least. The correlations between the LupusQoL domain scores and age (r = -0.01 to -0.22) and disease duration (r = 0 to 0.16) were absent or weak. Similarly, there were no significant differences in the LupusQoL scores regarding sex, marital status, or the 3 main ethnic groups (Black-Caribbean, Asian, White). Although there were statistically significant correlations between the scores of the LupusQoL domains and some scores of the British Isles Lupus Assessment Group index (r = -0.22 to 0.09) and the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (r = -0.29 to 0.21), these were weak. CONCLUSION: HRQOL was impaired in this cohort of outpatients with SLE as assessed by the validated lupus-specific LupusQoL. There were no clinically important associations between the 8 domains of the LupusQoL and clinical or demographic variables in this group of patients. Thus, the LupusQoL is a relatively independent outcome measure in patients with SLE. |
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Authors:
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Kathleen McElhone; Madhura Castelino; Janice Abbott; Ian N Bruce; Yasmeen Ahmad; Joanna Shelmerdine; Kate Peers; David Isenberg; Ada Ferenkeh-Koroma; Bridget Griffiths; Mohammed Akil; Peter Maddison; Caroline Gordon; Lee-Suan Teh |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-01 |
Journal Detail:
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Title: The Journal of rheumatology Volume: 37 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-02 Completed Date: 2011-02-11 Revised Date: 2011-12-01 |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: Canada |
Other Details:
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Languages: eng Pagination: 2273-9 Citation Subset: IM |
Affiliation:
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Department of Rheumatology, Administration Block, Level 1, Royal Blackburn Hospital, Haslingden Road, Blackburn BB2 3HH, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Fatigue / complications, physiopathology*, psychology Female Health Status Humans Lupus Erythematosus, Systemic / complications, physiopathology*, psychology Male Middle Aged Pain / complications, physiopathology*, psychology Quality of Life* Questionnaires Severity of Illness Index |
| Grant Support | |
ID/Acronym/Agency:
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//Arthritis Research UK |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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