Document Detail

Lupus nephropathy and pregnancy. Report of 104 cases in 36 patients.
MedLine Citation:
PMID:  7073417     Owner:  NLM     Status:  MEDLINE    
The reciprocal influence of lupus nephropathy on the outcome of pregnancy and of pregnancy on the course of renal involvement was studied retrospectively in a series of 106 pregnancies observed during the past two decades in 36 patients with lupus nephropathy. The overall incidence of live births, corrected for induced abortions, was 54 (84%) in 64 pregnancies that began before clinical onset of systemic lupus erythematosus (SLE), 20 (87%) in 23 pregnancies that began after onset of SLE, and only four (57%) in seven cases where SLE was first manifested during or after gestation. Relapse or exacerbation of disease activity occurred in 12 (46%) of 26 pregnancies antedated by clinical onset of SLE, more frequently during gestation than post partum, with two cases (8%) of irreversible deterioration of renal function; clinical exacerbation of lupus disease was observed in 11 (66%) of 15 cases where SLE was clinically active at the time of conception, and in only one (9%) of 11 cases where SLE nephritis was in stable clinical remission for at least five months before conception. The data indicate that successful outcome of pregnancy may be expected even in the more severe forms of lupus nephritis if gestation begins after a sustained, complete clinical remission.
P Jungers; M Dougados; C Pélissier; F Kuttenn; F Tron; P Lesavre; J F Bach
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of internal medicine     Volume:  142     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1982 Apr 
Date Detail:
Created Date:  1982-06-14     Completed Date:  1982-06-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  771-6     Citation Subset:  AIM; IM    
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MeSH Terms
Abortion, Spontaneous / etiology
Adrenal Cortex Hormones / therapeutic use
Kidney Diseases / etiology,  physiopathology*
Lupus Erythematosus, Systemic / complications,  physiopathology*
Pregnancy Complications / physiopathology*
Reg. No./Substance:
0/Adrenal Cortex Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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