| Lupus mesenteric vasculitis can cause acute abdominal pain in patients with SLE. | |
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MedLine Citation:
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PMID: 19412194 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lupus mesenteric vasculitis (LMV) is a unique clinical entity found in patients who present with gastrointestinal manifestations of systemic lupus erythematosus, and is the main cause of acute abdominal pain in these patients. LMV usually presents as acute abdominal pain with sudden onset, severe intensity and diffuse localization. Other causes of abdominal pain, such as acute gastroenteritis, peptic ulcers, acute pancreatitis, peritonitis, and other reasons for abdominal surgery should be ruled out. Prompt and accurate diagnosis of LMV is critical to ensure implementation of appropriate immunosuppressive therapy and avoidance of unnecessary surgical intervention. The pathology of LMV comprises immune-complex deposition and complement activation, with subsequent submucosal edema, leukocytoclastic vasculitis and thrombus formation; most of these changes are confined to small mesenteric vessels. Abdominal CT is the most useful tool for diagnosing LMV, which is characterized by the presence of target signs, comb signs, and other associated findings. The presence of autoantibodies against phospholipids and endothelial cells might provide information about the likelihood of recurrence of LMV. Immediate, high-dose, intravenous steroid therapy can lead to a favorable outcome and prevent serious complications such as bowel ischemia, necrosis and perforation. |
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Authors:
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Ji Hyeon Ju; Jun-Ki Min; Chan-Kwon Jung; Soon Nam Oh; Seung-Ki Kwok; Kwi Young Kang; Kyung-Su Park; Hyuk-Jae Ko; Chong-Hyeon Yoon; Sung-Hwan Park; Chul-Soo Cho; Ho-Youn Kim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nature reviews. Rheumatology Volume: 5 ISSN: 1759-4804 ISO Abbreviation: Nat Rev Rheumatol Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-04 Completed Date: 2009-07-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101500080 Medline TA: Nat Rev Rheumatol Country: England |
Other Details:
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Languages: eng Pagination: 273-81 Citation Subset: IM |
Affiliation:
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Rheumatology Division, College of Medicine, Catholic University of Korea, Seocho-Gu, Seoul, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdomen, Acute
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diagnosis,
etiology*,
physiopathology Acute Disease Autoantibodies / blood Complement Activation Diagnosis, Differential Gastroenteritis / diagnosis Humans Immune Complex Diseases / etiology, pathology Lupus Erythematosus, Systemic / complications*, diagnosis, physiopathology Mesenteric Arteries / pathology, radiography Mesenteric Veins / pathology, radiography Mesentery / blood supply Pancreatitis / diagnosis Peptic Ulcer / diagnosis Peritonitis / diagnosis Radiography, Abdominal Vasculitis / diagnosis, etiology*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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