| Lupus erythematosus-like imiquimod reaction: a diagnostic pitfall(*). | |
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MedLine Citation:
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PMID: 20726930 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Imiquimod (AldaraTM), a Toll-like receptor 7 agonist (TLR7), is known for its unique properties of being an immune response modifier and stimulator. Upon topical application, this TLR7 agonist triggers a cell-mediated immune response predominantly expressed by dendritic cells and monocytes. Local skin irritation at the application site involving erythema, pain, crusting and erosions is common and well documented. On the contrary, the specific histopathologic features associated with these treatment site reactions is not. Herein reported is a case where historical omission of imiquimod use for actinic keratosis complicated the histologic interpretation. We highlight a lupus erythematosus-like microscopic pattern and explore histopathologic features that could help in avoiding a diagnostic pitfall, as well as the relationship between TLR activation, cell-mediated immunity and skin histology. Barr KL, Konia TH, Fung MA. Lupus erythematosus-like imiquimod reaction: a diagnostic pitfall. |
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Authors:
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Keira L Barr; Thomas H Konia; Maxwell A Fung |
Publication Detail:
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Type: Journal Article Date: 2010-08-18 |
Journal Detail:
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Title: Journal of cutaneous pathology Volume: 38 ISSN: 1600-0560 ISO Abbreviation: J. Cutan. Pathol. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-02-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0425124 Medline TA: J Cutan Pathol Country: Denmark |
Other Details:
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Languages: eng Pagination: 346-50 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 John Wiley & Sons A/S. |
Affiliation:
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Departments of Dermatology and Pathology, University of California Davis Medical Center, Sacramento, CA, USA. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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