Document Detail

Lupus anticoagulants: diagnostic dilemma and clinical challenge.
MedLine Citation:
PMID:  10169622     Owner:  NLM     Status:  MEDLINE    
Lupus anticoagulants (LAs) are immunoglobulins which prolong 1 or more of the in vitro phospholipid-dependent tests of coagulation (e.g., activated partial thromboplastin time [APTT], dilute Russell viper venom time [dRVVT], kaolin clotting time [KCT], and textarin time [TT]). Paradoxically, patients with LAs rarely experience hemorrhagic problems. Approximately 1/3 of individuals with LAs experience thromboembolic complications such as stroke, deep vein thrombosis, and pulmonary emboli. LAs are members of the antiphospholipid antibody (APA) family. The APA family includes: LAs, anticardiolipin antibodies (ACAs), and reagin (the antibody responsible for the positive serologic test for syphilis). In approximately 60% of the patients, a LA and an ACA will both be present. The diagnosis of LAs requires an organized approach. Careful preparation of platelet poor plasma (PPP) is essential to assure maximum detection of LA. In order to rule out LAs, it is necessary to perform at least 2 screening tests (e.g., APTT, dRVVT). Additional steps in the diagnosis of LAs include mixing studies to identify the presence of an inhibitor and confirmatory procedures to demonstrate phospholipid-dependence of the inhibitor. It is also important to rule out any other potential coagulopathies which may account for the prolonged screening studies.
D A Triplett
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical laboratory science : journal of the American Society for Medical Technology     Volume:  10     ISSN:  0894-959X     ISO Abbreviation:  Clin Lab Sci     Publication Date:    1997 Jul-Aug
Date Detail:
Created Date:  1997-09-23     Completed Date:  1997-09-23     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8806547     Medline TA:  Clin Lab Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  223-8     Citation Subset:  T    
Midwest Hemostasis and Thrombosis Laboratories, Muncie, IN 47303, USA.
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MeSH Terms
Age Factors
Antiphospholipid Syndrome / diagnosis
Blood Coagulation Disorders / diagnosis*,  etiology
Blood Coagulation Tests / methods*
Lupus Coagulation Inhibitor / blood*
Reg. No./Substance:
0/Lupus Coagulation Inhibitor

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