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Lupus anticoagulant in patients with subarachnoid haemorrhage.
MedLine Citation:
PMID:  21427452     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background In aneurysmal subarachnoid haemorrhage (SAH), delayed cerebral ischaemia (DCI) is a serious complication that occurs in approximately 30% of patients. Lupus anticoagulant (LAC) is a risk factor for thrombotic events and has been associated with cerebral infarction after SAH. Objective To determine the frequency of LAC in patients with SAH and its association with DCI. Methods Patients with aneurysmal SAH from a prospectively collected database between 1998 and 2009 were included. Presence of LAC was detected with dilute Russell's viper venom time reagents. Investigation of the association with DCI was planned in case of an increased prevalence of LAC compared with the general population. Results Of 511 patients, LAC was detected in only six (1.2%; 95% CI 0.4 to 2.5%). In two of these six patients, DCI was diagnosed. Conclusion No evidence was found that LAC contributes to the development of DCI in patients with aneurysmal SAH.
Authors:
Francis A T M van Lier; Rolf T Urbanus; Nicolien K de Rooij; Gabriel J E Rinkel; Catherina C J Frijns
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-22
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  -     ISSN:  1468-330X     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands.
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