Document Detail

Lupus anticoagulant in immune thrombocytopenic purpura.
MedLine Citation:
PMID:  15226559     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Antibodies against phospholipid antigens (APA) have been demonstrated in adult idiopathic(immune) thrombocytopenic purpura (ITP), but their clinical and pathogenetic significance has remained elusive. Also there are no such studies available in pediatric ITP cases. In this study, the prevalence and clinical significance of APAs were investigated in pediatric patients with ITP. METHODS: Forty newly diagnosed ITP patients (age 2-13 years) were prospectively studied. They were evaluated for the presence of lupus anticoagulant (LA). RESULTS: Eleven patients (27.5%) were LA positive at the time of diagnosis. No statistically significant differences were found between the LA-positive and LA-negative groups regarding gender, initial platelet counts, or response to methyl prednisolone therapy. After 6 months of follow up, 5 of the 11 LA-positive cases were still positive for LA. The frequency of LA positivity found in this pediatric age group was similar to that reported in adult patients. CONCLUSION: In view of the fact that in adult patients with ITP, the persistent presence of APAs is an important risk factor for the development of antiphospholipid syndrome, the same may also hold true for pediatric ITP patients, and thus 'demands long term follow up for these patients.
Sumitra Dash; R K Marwaha; Sambit Mohanty
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of pediatrics     Volume:  71     ISSN:  0019-5456     ISO Abbreviation:  Indian J Pediatr     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-30     Completed Date:  2004-08-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417442     Medline TA:  Indian J Pediatr     Country:  India    
Other Details:
Languages:  eng     Pagination:  505-7     Citation Subset:  IM    
Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
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MeSH Terms
Child, Preschool
India / epidemiology
Lupus Coagulation Inhibitor / blood*
Prospective Studies
Purpura, Thrombocytopenic, Idiopathic / blood*,  epidemiology
Reg. No./Substance:
0/Lupus Coagulation Inhibitor

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