Document Detail


Lupus and pregnancy--15 years of experience in a tertiary center.
MedLine Citation:
PMID:  19557319     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This retrospective study was designed to evaluate the outcome of pregnancies in women diagnosed with systemic lupus erythematosus (SLE) followed in a tertiary fetal-maternal center. Data were collected from clinical charts between January 1993 and December 2007, with a total of 136 pregnancies (107 patients). Mean maternal age was 29 years, with the vast majority of patients being Caucasian. Most patients were in remission 6 months prior to pregnancy (93%) and the most frequently affected organs were the skin and joints. Renal lupus accounted for 14% of all cases. Twenty-nine percent of patients were positive for at least one antiphospholid antibody (aPL) and nearly 50% had positive SSa/SSb antibodies. All patients with positive aPL received low-dosage aspirin and low-molecular-weight heparin (LMWH). There were no pregnancy complications in more than 50% of cases and hypertensive disease and intrauterine growth restriction were the most common adverse events. There were 125 live births, one neonatal death, eight miscarriages, and three medical terminations of pregnancy. Preterm delivery occurred in 25% of pregnancies. Our results are probably the conjoined result of a multidisciplinary approach together with a systematic management of SLE pregnancies, with most patients keeping their prior SLE medication combined with low-dosage aspirin and LMWH in the presence of aPL.
Authors:
Paula Ambr?sio; Rita Lermann; Alexandra Cordeiro; Augusta Borges; Isabel Nogueira; F?tima Serrano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical reviews in allergy & immunology     Volume:  38     ISSN:  1559-0267     ISO Abbreviation:  Clin Rev Allergy Immunol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-30     Completed Date:  2010-06-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504368     Medline TA:  Clin Rev Allergy Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  77-81     Citation Subset:  IM    
Affiliation:
Department of Fetal-Maternal Medicine, Maternidade Dr. Alfredo da Costa, Lisbon, Portugal. paulaambrosio@netcabo.pt
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Humans
Infant, Newborn
Lupus Erythematosus, Systemic / complications*,  physiopathology*
Pregnancy
Pregnancy Complications / immunology,  physiopathology*
Pregnancy Outcome
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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