Document Detail


Lupin allergy: a hidden killer in the home.
MedLine Citation:
PMID:  20701610     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This review addresses the problem of lupin sensitization in the home environment. We summarize the data currently available on allergy to lupin, which has become, in recent years, a hidden killer in our homes. Since 2006, when lupin was included in European regulations as a food whose presence must be declared, the situation may have changed. Nevertheless, we must take into account the possibility of undeclared allergenic ingredients or the presence of 'hidden' allergens, given that contamination during food production processes may be a great risk for sensitized individuals. Furthermore, the United States, Japan, Australia and New Zealand still do not include lupin among the ingredients that must be listed on foodstuff labelling. Our responsibility is to educate the public so that they are aware of the danger and look for lupin in the labels of products that run the risk of containing it. Lupin allergy can manifest itself in isolation or in parallel to peanut allergy. Identification of the proteins causing possible cross-reactivity is complicated, and new structural studies are needed. To date, it has not been possible to clearly identify the allergens responsible for isolated lupin sensitization in relation to parallel and/or cross-sensitization between lupin and peanut. Most of the allergenic proteins of lupin are α- and β-conglutins, with a lesser presence of γ- and δ-conglutins. A β-conglutin corresponding to Lup an 1, with a sequence similar to Ara h 1, has been identified as a major allergen of lupin in patients with allergy following lupin ingestion.
Authors:
M L Sanz; M D de Las Marinas; J Fernández; P M Gamboa
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-08-04
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  40     ISSN:  1365-2222     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-12     Completed Date:  2011-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  England    
Other Details:
Languages:  eng     Pagination:  1461-6     Citation Subset:  IM    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
Affiliation:
Department of Allergology and Clinical Immunology, School of Medicine, University Clinic of Navarra, Pamplona, Spain. mlsanzlar@unav.es
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MeSH Terms
Descriptor/Qualifier:
Allergens / chemistry,  immunology
Fabaceae / chemistry,  immunology*
Food Hypersensitivity / immunology*
Humans
Seed Storage Proteins / immunology
Chemical
Reg. No./Substance:
0/Allergens; 0/Seed Storage Proteins; 1391-07-7/conglutin protein, Lupinus angustifolius

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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