Document Detail

Lupin allergy: a hidden killer at home, a menace at work; occupational disease due to lupin allergy.
MedLine Citation:
PMID:  20937061     Owner:  NLM     Status:  MEDLINE    
The products of the flowering plant, lupin, are increasingly used as a human food product, particularly in baking. Occupational sensitization to lupin with occupational rhinitis, conjunctivitis and asthma was first described in 2001, and confirmed in a larger cross-sectional study in a food processing company in 2006. Sensitization by inhalation may result in occupational asthma, work-exacerbated asthma, occupational rhinitis and conjunctivitis. The incidence of occupational sensitization may be as high as 29%. The relationship with exposure intensity is as yet unclear, and requires further clarification. Although there is little information from long-term studies, these diseases are likely to improve after cessation of exposure. Cross-sensitization to other legumes, particularly peanuts, has been shown by skin prick testing, with potential for serious anaphylactic reactions. This review summarizes the available literature on occupational sensitization to lupin products. It is one of two reviews, one covering the problem of lupin allergy in the home, while the present article deals with lupin sensitization in the workplace. Increased awareness is needed of this occupational hazard to avoid future cases of occupational disease and their accompanying morbidity and potential mortality.
C P Campbell; D H Yates
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  40     ISSN:  1365-2222     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-12     Completed Date:  2011-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  England    
Other Details:
Languages:  eng     Pagination:  1467-72     Citation Subset:  IM    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
Buckinghamshire NHS Hospitals Trust, High Wycombe, Bucks, UK.
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MeSH Terms
Cross Reactions
Fabaceae / immunology*
Food Hypersensitivity / epidemiology*,  immunology*
Middle Aged
Occupational Diseases / epidemiology*,  immunology*

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