Document Detail

Lungs in mixed connective tissue disease.
MedLine Citation:
PMID:  1578526     Owner:  NLM     Status:  MEDLINE    
Patients with mixed connective tissue disease (MCTD) exhibit clinical features of systemic lupus erythematosus (SLE), progressive systemic sclerosis or scleroderma (PSS), and polymyositis-dermatomyositis (PM-DM). In their sera is an unusually high titer of a circulating antinuclear antibody with specificity for a nuclear ribonucleoprotein antigen. Pleuropulmonary manifestations are common in MCTD and the incidence varies from 20% to 85%. The pleuropulmonary complications include pleural effusion, interstitial pulmonary processes, pulmonary arterial hypertension (PAH), pulmonary vasculitis, pulmonary thromboembolic phenomena, aspiration pneumonia, and hypoventilatory failure. Pulmonary vascular pathology with progressive PAH and cor pulmonale is the most serious complication of MCTD. The pleuropulmonary manifestations in MCTD are similar to the respiratory problems well recorded in SLE, PSS, and PM-DM. Even though the pleuropulmonary complications are common in MCTD, they may remain clinically inapparent until fatal complications ensue.
U B Prakash
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of thoracic imaging     Volume:  7     ISSN:  0883-5993     ISO Abbreviation:  J Thorac Imaging     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-06-09     Completed Date:  1992-06-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8606160     Medline TA:  J Thorac Imaging     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  55-61     Citation Subset:  IM    
Mayo Medical School, Rochester, Minnesota.
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MeSH Terms
Lung Diseases / diagnosis,  etiology*,  pathology
Mixed Connective Tissue Disease / complications*
Pleural Diseases / diagnosis,  etiology,  pathology

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