Document Detail

Lung water, hemodynamics and dyspnea before and after valvuloplasty in mitral stenosis.
MedLine Citation:
PMID:  11077137     Owner:  NLM     Status:  MEDLINE    
The investigation was to elucidate the role of the reduction of extravascular pulmonary fluid in the immediate symptomatic improvement and its impact on hemodynamics in patients with mitral stenosis treated by percutaneous transluminal valvuloplasty. METHODS: In a prospective study of 12 patients with severe mitral stenosis extravascular pulmonary fluid volume was determined by a combined dye and thermodilution technique (COLD Z-021(TM) Version 5.x, Pulsion((R))) before and after valvuloplasty. Cardiac output, left atrial pressures, atrial V-waves, diastolic transmitral gradients and their respiratory changes were measured. Dyspnea was assessed by validated questionnaires. RESULTS: Symptomatic improvement correlated (r=0. 808) with a decrease of extravascular lung water, but not with either an increase or a decrease of cardiac output or left atrial filling pressures. The decrease of the lung water index may be predicted from the lung water index before valvuloplasty, the final left atrial mean pressure and the cardiac index prior to intervention. The change of the mean difference between inspiratory and expiratory mitral gradient demonstrated a significant inverse correlation with the change of mean left atrial filling pressures (r=-0.778) and with extravascular lung water after valvuloplasty (r=-0.871). CONCLUSION: There is a complex relationship between left atrial filling pressures, extravascular lung water, respiratory changes of gradients, and dyspnea that need further investigation.
E Wellnhofer; C Cramer; S Dreysse; E Fleck
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  75     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-12-18     Completed Date:  2001-01-11     Revised Date:  2010-05-10    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  217-25     Citation Subset:  IM    
Department of Internal Medicine/Cardiology, Campus Virchow-Klinikum, Charit?, Humboldt Universit?t zu Berlin, Berlin, Germany.
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MeSH Terms
Cardiac Surgical Procedures
Dyspnea / etiology*,  physiopathology
Extravascular Lung Water*
Middle Aged
Mitral Valve Stenosis / physiopathology*,  surgery*
Postoperative Period
Prospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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