Document Detail


Lung volume restriction in patients with chronic respiratory muscle weakness: the role of microatelectasis.
MedLine Citation:
PMID:  8153916     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: It is well established that patients with longstanding weakness of the respiratory muscles have a reduction in lung distensibility. Although this occurs in most patients without any radiographic changes suggesting parenchymal lung disease, it has been attributed to the development of microatelectasis. METHODS: A high resolution computed tomographic (CT) scanner was used in eight patients with traumatic tetraplegia and six patients with generalised neuromuscular disorders to look for areas of atelectasis. With the patient in the supine posture scans of 1 mm thickness were obtained at total lung capacity at intervals of 1 cm from the apex to the base of the lung. RESULTS: Vital capacity, total lung capacity, and inspiratory muscle strength were reduced to a mean of 59.5%, 73.9%, and 51.1% of predicted values, respectively. Static expiratory lung compliance was decreased in 12 of the 14 patients and averaged 69.1% of the predicted value. The CT scans revealed only small areas of atelectasis in one tetraplegic patient and in one patient with a generalised neuromuscular disorder; no parenchymal abnormality was seen in the other 12 patients. CONCLUSIONS: In many patients with chronic weakness of the respiratory muscles the reduced lung distensibility does not appear to be caused by microatelectasis. It might be related to alterations in elasticity of the lung tissue.
Authors:
M Estenne; P A Gevenois; W Kinnear; P Soudon; A Heilporn; A De Troyer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thorax     Volume:  48     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1994-05-10     Completed Date:  1994-05-10     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  698-701     Citation Subset:  IM    
Affiliation:
Chest Service, Erasme University Hospital, Brussels, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Chronic Disease
Female
Humans
Lung / radiography
Lung Compliance
Lung Volume Measurements*
Male
Middle Aged
Muscle Contraction
Neuromuscular Diseases / complications*
Pulmonary Atelectasis / complications,  physiopathology*,  radiography
Quadriplegia / complications
Respiratory Muscles / physiopathology*
Tomography, X-Ray Computed
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