Document Detail

Lung volume and VA/Q distribution response to intravenous versus inhalation anesthesia in sheep.
MedLine Citation:
PMID:  6742484     Owner:  NLM     Status:  MEDLINE    
The effects of intravenous pentobarbital versus nitrous oxide/halothane inhalation anesthesia on blood gases, distribution of ventilation-perfusion ratios (VA/Q), and lung volume (FRC) were compared in 8 tracheostomized sheep in the lateral decubitus position. Pentobarbital anesthesia produced no significant changes (from awake control) in arterial blood PO2 or PCO2, ventilation-perfusion inequality, intrapulmonary shunt, or FRC during either spontaneous breathing or mechanical ventilation with muscle paralysis. With inhalation anesthesia, PaO2 decreased from 132 +/- 13 mmHg awake to 106 +/- 11 mmHg and 104 +/- 6 mmHg (FIO2 all 0.3) during spontaneous and mechanical ventilation. Shunt increased from 1.4 +/- 1.0% awake to 10.6 +/- 4.5 and 13.9 +/- 5.3%, respectively. Mean VA/Q decreased from 0.39 +/- 0.07 awake, to 0.21 +/- 0.06 and 0.29 +/- 0.07. Log standard deviation of VA/Q increased from 0.66 +/- 0.12 awake to 0.83 +/- 0.28 and 0.89 +/- 0.15. FRC decreased from 1.66 +/- 0.65 1 to 1.46 +/- 0.62 and 1.22 +/- 0.63 1, respectively. Differences in response to intravenous versus inhalation anesthesia for the above variables all were statistically significant at P less than 0.05. FRC and shunt changes with anesthesia showed significant correlation for both spontaneous (r = -0.80) and mechanical ventilation (r = 0.77), P less than 0.005 for both. We therefore propose that the differences between lung volume and gas exchange effects of intravenous versus inhalation anesthesia in sheep may have been related causally.
R Dueck; M Rathbun; A G Greenburg
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Anesthesiology     Volume:  61     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-07-31     Completed Date:  1984-07-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  55-65     Citation Subset:  AIM; IM    
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MeSH Terms
Anesthesia, Inhalation
Halothane / administration & dosage*,  pharmacology
Injections, Intravenous
Lung / drug effects*
Lung Volume Measurements
Nitrous Oxide / administration & dosage*,  pharmacology
Pentobarbital / administration & dosage*,  pharmacology
Ventilation-Perfusion Ratio / drug effects*
Reg. No./Substance:
10024-97-2/Nitrous Oxide; 151-67-7/Halothane; 76-74-4/Pentobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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