Document Detail


Lung volume and VA/Q distribution response to intravenous versus inhalation anesthesia in sheep.
MedLine Citation:
PMID:  6742484     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of intravenous pentobarbital versus nitrous oxide/halothane inhalation anesthesia on blood gases, distribution of ventilation-perfusion ratios (VA/Q), and lung volume (FRC) were compared in 8 tracheostomized sheep in the lateral decubitus position. Pentobarbital anesthesia produced no significant changes (from awake control) in arterial blood PO2 or PCO2, ventilation-perfusion inequality, intrapulmonary shunt, or FRC during either spontaneous breathing or mechanical ventilation with muscle paralysis. With inhalation anesthesia, PaO2 decreased from 132 +/- 13 mmHg awake to 106 +/- 11 mmHg and 104 +/- 6 mmHg (FIO2 all 0.3) during spontaneous and mechanical ventilation. Shunt increased from 1.4 +/- 1.0% awake to 10.6 +/- 4.5 and 13.9 +/- 5.3%, respectively. Mean VA/Q decreased from 0.39 +/- 0.07 awake, to 0.21 +/- 0.06 and 0.29 +/- 0.07. Log standard deviation of VA/Q increased from 0.66 +/- 0.12 awake to 0.83 +/- 0.28 and 0.89 +/- 0.15. FRC decreased from 1.66 +/- 0.65 1 to 1.46 +/- 0.62 and 1.22 +/- 0.63 1, respectively. Differences in response to intravenous versus inhalation anesthesia for the above variables all were statistically significant at P less than 0.05. FRC and shunt changes with anesthesia showed significant correlation for both spontaneous (r = -0.80) and mechanical ventilation (r = 0.77), P less than 0.005 for both. We therefore propose that the differences between lung volume and gas exchange effects of intravenous versus inhalation anesthesia in sheep may have been related causally.
Authors:
R Dueck; M Rathbun; A G Greenburg
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Anesthesiology     Volume:  61     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-07-31     Completed Date:  1984-07-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  55-65     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Anesthesia, Inhalation
Animals
Halothane / administration & dosage*,  pharmacology
Injections, Intravenous
Lung / drug effects*
Lung Volume Measurements
Nitrous Oxide / administration & dosage*,  pharmacology
Pentobarbital / administration & dosage*,  pharmacology
Sheep
Ventilation-Perfusion Ratio / drug effects*
Wakefulness
Chemical
Reg. No./Substance:
10024-97-2/Nitrous Oxide; 151-67-7/Halothane; 76-74-4/Pentobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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