Document Detail


Lung volume, closing volume, and gas exchange.
MedLine Citation:
PMID:  7107456     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of a voluntary reduction in lung volume on arterial O2 saturation (SaO2) was studied in 10 normal subjects aged 19-63 yr. SaO2 was measured by ear oximetry first during tidal breathing at functional residual capacity, and then during tidal breathing at 380 ml above residual volume. Tidal volume and breathing frequency were kept constant, and end-tidal CO2 partial pressure remained stable or fell in 9 out of 10 subjects. When lung volume was reduced, SaO2 fell by a mean of 1.5% (range 0-3%). Closing volume (CV) was measured by the N2-washout method (mean 0.89 liter, range 0.41-1.44). There was a close correlation between CV and the fall in SaO2 (r = 0.867, P = 0.001). Arterial and mixed venous CO2 were measured in one subject; the results indicated some fall in cardiac output following the lung volume change, but this accounted for less than half of the fall in SaO2. The relationship between CV and the lung volume at which tidal breathing occurs is an important determinant of pulmonary gas exchange through its effect on the matching of ventilation to perfusion.
Authors:
S C Morrison; D G Stubbing; P V Zimmerman; E J Campbell
Related Documents :
7313346 - Supernormal maximal mid-expirartory flow rates in diffuse interstitial lung disease.
23842586 - High-flow nasal prong oxygen therapy or nasopharyngeal continuous positive airway press...
9834796 - Effects of recruitment of collapsed lung units on the elastic pressure-volume relations...
422456 - A system for rapid measurement of lung function in small animals.
22288836 - Relationship between positive end-expiratory pressure and internal jugular vein cross-s...
11703016 - Pressure profilometry of the lumbosacral disk in dogs.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  52     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-10-12     Completed Date:  1982-10-12     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1453-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Arteries
Closing Volume
Functional Residual Capacity
Humans
Male
Middle Aged
Oxygen / blood
Respiration*
Smoking
Ventilation-Perfusion Ratio
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Comparison of capsular and intra-alveolar fluid pressures in the lung.
Next Document:  Effects of gravity and branching on longitudinal gas mixing in glass tube models.