| Lung vascular permeability changes in lambs with hyaline membrane disease. | |
| | |
MedLine Citation:
|
PMID: 2640230 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To investigate the mechanism of pulmonary edema in hyaline membrane disease (HMD), lymph from the efferent duct of the mediastinal lymph node was collected in premature lambs before and after delivery by cesarean section. Mean lymph flow in 7 lambs with histologically verified HMD increased progressively over 4 h after delivery to 3 times the fetal value, while lymph flow in 7 lambs without HMD increased to 3.5 times at 1 h and decreased thereafter. At 4 h after birth, lung lymph flow was significantly higher in lambs with HMD than in lambs without HMD (0.70 +/- 0.15 (SEM) vs 0.43 +/- 0.07 ml.h-1.kg-1). Lymph/plasma concentration ratio for small endogenous protein fractions (effective molecular radius, 3.6 and 3.8 nm) was significantly higher in lambs with HMD than in lambs without HMD at 2-4 h. Postmortem extravascular lung water was significantly higher in lambs with HMD (6.1 +/- 0.5 vs 4.3 +/- 0.3 ml/g dry lung weight). It is concluded that lung water is high in lambs with HMD, which appears to be a result both of delayed absorption of fetal lung liquid and increased permeability of the pulmonary exchange vessels. |
| | |
Authors:
|
H W Sundell; J Grogaard; J Rojas; M E Gray; P Mohan; K L Brigham |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of developmental physiology Volume: 12 ISSN: 0141-9846 ISO Abbreviation: J. Dev. Physiol. Publication Date: 1989 Dec |
Date Detail:
|
Created Date: 1990-08-30 Completed Date: 1990-08-30 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7910737 Medline TA: J Dev Physiol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 353-62 Citation Subset: IM |
Affiliation:
|
Newborn Lung Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Gas Analysis Blood Proteins / analysis Capillary Permeability* Heart Rate Humans Hyaline Membrane Disease / complications, pathology, physiopathology* Infant, Newborn Lung / anatomy & histology, physiopathology* Lymph / analysis Organ Size Pulmonary Edema / etiology Pulmonary Ventilation / physiology Water / pharmacokinetics |
| Grant Support | |
ID/Acronym/Agency:
|
HL 14214/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Blood Proteins; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Calibration of respiratory inductive plethysmography during quiet and active sleep in lambs.
Next Document: Chronic vascular catheters in growing piglets.