Document Detail

Lung vascular permeability changes in lambs with hyaline membrane disease.
MedLine Citation:
PMID:  2640230     Owner:  NLM     Status:  MEDLINE    
To investigate the mechanism of pulmonary edema in hyaline membrane disease (HMD), lymph from the efferent duct of the mediastinal lymph node was collected in premature lambs before and after delivery by cesarean section. Mean lymph flow in 7 lambs with histologically verified HMD increased progressively over 4 h after delivery to 3 times the fetal value, while lymph flow in 7 lambs without HMD increased to 3.5 times at 1 h and decreased thereafter. At 4 h after birth, lung lymph flow was significantly higher in lambs with HMD than in lambs without HMD (0.70 +/- 0.15 (SEM) vs 0.43 +/- 0.07 Lymph/plasma concentration ratio for small endogenous protein fractions (effective molecular radius, 3.6 and 3.8 nm) was significantly higher in lambs with HMD than in lambs without HMD at 2-4 h. Postmortem extravascular lung water was significantly higher in lambs with HMD (6.1 +/- 0.5 vs 4.3 +/- 0.3 ml/g dry lung weight). It is concluded that lung water is high in lambs with HMD, which appears to be a result both of delayed absorption of fetal lung liquid and increased permeability of the pulmonary exchange vessels.
H W Sundell; J Grogaard; J Rojas; M E Gray; P Mohan; K L Brigham
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of developmental physiology     Volume:  12     ISSN:  0141-9846     ISO Abbreviation:  J. Dev. Physiol.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-08-30     Completed Date:  1990-08-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7910737     Medline TA:  J Dev Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  353-62     Citation Subset:  IM    
Newborn Lung Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
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MeSH Terms
Blood Gas Analysis
Blood Proteins / analysis
Capillary Permeability*
Heart Rate
Hyaline Membrane Disease / complications,  pathology,  physiopathology*
Infant, Newborn
Lung / anatomy & histology,  physiopathology*
Lymph / analysis
Organ Size
Pulmonary Edema / etiology
Pulmonary Ventilation / physiology
Water / pharmacokinetics
Grant Support
Reg. No./Substance:
0/Blood Proteins; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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