Document Detail

Lung vascular effects of lipid infusion in awake lambs.
MedLine Citation:
PMID:  3431956     Owner:  NLM     Status:  MEDLINE    
Numerous reports have shown that intravascular lipid infusion may cause pulmonary dysfunction in a variety of species, including humans. To determine the effects of parenteral lipid on neonatal pulmonary hemodynamics, lung fluid filtration, and respiratory gas exchange, we measured pulmonary arterial and left atrial pressures, cardiac output, lung lymph flow, lymph and plasma protein concentrations, and partial pressures of oxygen and carbon dioxide in arterial blood of 11 awake chronically catheterized lambs that received a 2-3 h control infusion of glucose-saline solution followed by Intralipid at a dose of 67.5, 125, or 250 (mg/h)/kg body weight for 6 h. Intralipid caused an acute dose-dependent increase in pulmonary arterial pressure, with no significant change in cardiac output or left atrial pressure. The pulmonary hypertension, which lasted for at least 2 h, was accompanied by a greater than 50% increase in lung lymph flow and a significant decrease in lymph protein concentration relative to plasma protein concentration. Pulmonary artery pressure gradually decreased to control values during the final 2 h of lipid infusion, but lymph flow remained 35% above control and lymph protein concentration remained low. Lipid infusion also was associated with a modest decrease in PaO2. Both arterial and venous administration of lipid gave similar results. In separate studies, lipid infusion caused a significant increase in plasma concentrations of thromboxane B2, the stable metabolite of thromboxane A2, without affecting plasma concentrations of 6-keto prostaglandin F1 alpha, the stable metabolite of prostacyclin. Pretreatment with imidazole, which attenuated the lipid-induced increase in thromboxane B2 concentration, completely blocked the pulmonary hemodynamic response to lipid.(ABSTRACT TRUNCATED AT 250 WORDS)
W G Teague; J U Raj; D Braun; M E Berner; R I Clyman; R D Bland
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric research     Volume:  22     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-02-26     Completed Date:  1988-02-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  714-9     Citation Subset:  IM    
Department of Pediatrics University of California, San Francisco 94143.
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MeSH Terms
Animals, Newborn
Fat Emulsions, Intravenous / toxicity*
Imidazoles / pharmacology
Lymph / drug effects,  physiology
Pulmonary Circulation / drug effects*
Thromboxane A2 / physiology
Thromboxane-A Synthase / antagonists & inhibitors
Grant Support
Reg. No./Substance:
0/Fat Emulsions, Intravenous; 0/Imidazoles; 288-32-4/imidazole; 57576-52-0/Thromboxane A2; EC Synthase

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