Document Detail

Lung uptake of technetium-99m tetrofosmin in healthy subjects is related to smoking habits.
MedLine Citation:
PMID:  11978957     Owner:  NLM     Status:  MEDLINE    
To determine the influence of smoking on lung uptake of technetium-99m tetrofosmin (Tc-TF) during myocardial perfusion imaging, we examined 50 healthy subjects with normal myocardial perfusion single photon emission computed tomography findings, normal coronary angiograms, and no evidence of left ventricular hypertrophy. The 50 healthy subjects were divided into two groups. Group 1: 25 healthy subjects had smoking histories of at least 10 pack-years. Group 2: 25 healthy subjects were nonsmokers. Lung to heart ratios (L/H ratios) calculated from anterior planar images during exercise and rest states of Tc-TF myocardial perfusion imaging were obtained for all of the 50 healthy subjects. L/H ratios calculated from Tc-TF myocardial perfusion imaging in smokers were significantly higher than in nonsmokers during both exercise and rest states. However, no significant difference in L/H ratios was found between exercise and rest states in smokers and nonsmokers. In addition, a positive but nonsignificant correlation was found between smoking pack-years and either rest or exercise L/H ratios. When L/H ratios are used as a clinical diagnostic tool in Tc-TF myocardial perfusion imaging, we must consider that L/H ratios in smokers are higher than in nonsmokers.
Shi Sheng Tsou; Yu-Chien Shiau; Chia-Hung Kao; Cheng Chieh Lin; Cheng Chun Lee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiology     Volume:  97     ISSN:  0008-6312     ISO Abbreviation:  Cardiology     Publication Date:  2002  
Date Detail:
Created Date:  2002-04-29     Completed Date:  2002-08-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  99-103     Citation Subset:  IM    
Copyright Information:
Copyright 2002 S. Karger AG, Basel
Division of Cardiology, China Medical College Hospital, Taichung, Taiwan, ROC.
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MeSH Terms
Exercise Test
Heart / radionuclide imaging
Lung / metabolism*,  radionuclide imaging
Middle Aged
Myocardium / metabolism*
Organophosphorus Compounds / pharmacokinetics*
Organotechnetium Compounds / pharmacokinetics*
Radiopharmaceuticals / pharmacokinetics*
Retrospective Studies
Sensitivity and Specificity
Smoking / metabolism*
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:
0/Organophosphorus Compounds; 0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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