| Lung transplantation for cystic fibrosis: current concepts and one center's experience. | |
| | |
MedLine Citation:
|
PMID: 17418647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Although new approaches to the treatment of patients with cystic fibrosis (CF) are significantly prolonging their lives, most patients will eventually develop respiratory failure due to progressive bronchiectasis caused by chronic lung infection and inflammation and die from to respiratory failure. We examined our center's (University of Wisconsin Hospital and Clinics) experience with lung transplantation for patients with CF and reviewed the literature to examine current and evolving approaches to transplantation for this indication. METHODS: We reviewed all published literature pertaining to lung transplantation for CF through 2006, and we reviewed all aspects of transplantation for patients with CF at our institution from 1994 to 2005. RESULTS: Major complications following lung transplantation include acute rejection, bacterial infection, and bronchiolitis obliterans. Five-year survival at UWHC (Kaplan-Meier) is 67%, and survival was not adversely affected by transplanting patients receiving mechanical ventilation. The major cause of death for transplant recipients was bronchiolitis obliterans syndrome (BOS). CONCLUSIONS: Lung transplantation for CF is associated with acceptable survival rates and can improve quality of life. Lung transplant should be offered to all patients with advanced CF lung disease if they meet currently accepted inclusion and exclusion criteria. |
| | |
Authors:
|
J E Spahr; R B Love; M Francois; K Radford; K C Meyer |
Related Documents
:
|
16088677 - Pathophysiology of acute lung injury. 18351547 - Prevalence of cystic echinococcosis in slaughtered cattle in afyonkarahisar. 3547657 - Gold lung: recent developments in pathogenesis, diagnosis, and therapy. 3302187 - Diffusing lung capacity and cyclosporine in patients with heart transplants. 16088677 - Pathophysiology of acute lung injury. 16685677 - Ischemic type biliary lesions in histidine-tryptophan-ketoglutarate (htk) preserved liv... |
Publication Detail:
|
Type: Journal Article; Review Date: 2007-04-05 |
Journal Detail:
|
Title: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society Volume: 6 ISSN: 1569-1993 ISO Abbreviation: J. Cyst. Fibros. Publication Date: 2007 Sep |
Date Detail:
|
Created Date: 2007-09-03 Completed Date: 2008-01-29 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101128966 Medline TA: J Cyst Fibros Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 334-50 Citation Subset: IM |
Affiliation:
|
University of Wisconsin School of Medicine and Public Health, WI, USA. jonathan.spahr@chp.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Cause of Death Cystic Fibrosis / surgery* Female Humans Lung Transplantation* / mortality Male Postoperative Complications Quality of Life Survival Rate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A new framework for identifying combinatorial regulation of transcription factors: a case study of t...
Next Document: Control of electroosmotic flow by a cation additive to enhance the separation of amino acids by mice...