Document Detail

Lung structure and function of infants with recurrent wheeze when asymptomatic.
MedLine Citation:
PMID:  18715876     Owner:  NLM     Status:  MEDLINE    
Infants with recurrent wheeze have repeated episodes of airways obstruction; however, relatively little is known about the structure and function of their lungs when not symptomatic. The current authors evaluated whether infants with recurrent wheeze have smaller airway lumens or thickened airway walls, as well as decreased airway function. High-resolution computed tomography images 1 mm thick were obtained at three anatomic locations at an elevated lung volume and at functional residual capacity. Forced expiratory flows were also measured in subjects with recurrent wheeze. Airway lumen, wall areas and lung tissue density were not significantly different for recurrent wheeze (n = 17) and control (n = 14) subjects; however, subjects with recurrent wheeze had lower forced expiratory flows than predicted. Similar findings were obtained when subjects were grouped by exposure to tobacco smoke. These findings indicate that infants with recurrent wheeze, as well as exposure to tobacco smoke, have lower airway function when not symptomatic. The lower forced expiratory flows may result from a degree of airway narrowing that could not be resolved with the methodology employed or from other mechanisms, such as more collapsible airways or decreased pulmonary elastic recoil.
C J Llapur; T M Martínez; C Coates; C Tiller; J L Wiebke; X Li; K Applegate; H O Coxson; R S Tepper
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-08-20
Journal Detail:
Title:  The European respiratory journal     Volume:  33     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-01     Completed Date:  2009-05-06     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  107-12     Citation Subset:  IM    
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MeSH Terms
Body Mass Index
Case-Control Studies
Child, Preschool
Lung / pathology*,  physiopathology*,  radiography
Respiratory Function Tests
Respiratory Sounds / diagnosis*,  etiology,  physiopathology*
Tobacco Smoke Pollution
Tomography, X-Ray Computed
Grant Support
54062//PHS HHS; R01 HL054062/HL/NHLBI NIH HHS; R01 HL054062-12/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Tobacco Smoke Pollution

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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