Document Detail

Lung protective ventilatory strategies in very low birth weight infants.
MedLine Citation:
PMID:  18446177     Owner:  NLM     Status:  MEDLINE    
Respiratory distress syndrome (RDS) is the most common respiratory diagnosis in preterm infants. Surfactant therapy and mechanical ventilation using conventional or high-frequency ventilation have been the standard of care in the management of RDS. Bronchopulmonary dysplasia (BPD) continues to remain as a major morbidity in very low birth weight infants despite these treatments. There is no significant difference in pulmonary outcome when an optimal lung volume strategy is used with conventional or high-frequency ventilation. Lung injury is directly related to the duration of invasive ventilation via the endotracheal tube. Studies using noninvasive ventilation, such as nasal continuous positive airway pressure and noninvasive positive pressure ventilation, have shown to decrease postextubation failures as well as a trend toward reduced risk of BPD. Lung protective ventilatory strategy may involve noninvasive ventilation as a primary therapy or following surfactant administration in very preterm infants with RDS. Initial steps in the management of preterm infants may also include sustained inflation to establish functional residual capacity, followed by noninvasive ventilation to minimize lung injury and subsequent development of BPD.
R Ramanathan; S Sardesai
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  28 Suppl 1     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-30     Completed Date:  2008-09-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S41-6     Citation Subset:  IM    
Division of Neonatal Medicine, Department of Pediatrics, Women's and Children's Hospital and Childrens Hospital Los Angeles, Keck School of Medicine University of Southern California, Los Angeles, CA, USA.
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MeSH Terms
Bronchopulmonary Dysplasia / etiology,  prevention & control*
Continuous Positive Airway Pressure*
Functional Residual Capacity
High-Frequency Ventilation*
Infant, Newborn
Infant, Very Low Birth Weight*
Intubation, Intratracheal
Positive-Pressure Respiration*
Pulmonary Surfactants / administration & dosage
Respiratory Distress Syndrome, Newborn / therapy*
Risk Factors
Reg. No./Substance:
0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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