Document Detail

Lung pathology in infants with severe pulmonary hypertension and cardiac disease.
MedLine Citation:
PMID:  431107     Owner:  NLM     Status:  MEDLINE    
Lung biopsy specimens were taken from 39 infants younger than 12 months of age with congenital heart disease and severe pulmonary hypertension (Pp/Ps greater than or equal to 0.75) accompanied by respiratory distress. The pathological change in lung specimens and clinical courses were compared. These 39 infants underwent surgical treatment of patent ductus arteriosus (PDA), seven patients; ventricular septal defect (VSD), 13 patients; and complex heart anomaly, 19 patients. The common pathological findings of the lung specimens taken from these infants were lymphoid cellular infiltration and thickening of the alveolar septum, which we have called "septitis" in the present study. In most cases pulmonary vascular obstructive change was within Grade 2 of the Health-Edwards criteria. Septitis was classified into three categories: mild, moderate, and severe. Only three of the 19 infants with severe septitis survived postoperatively, whereas 10 of the 12 infants with moderate septitis and all eight with mild septitis could be successfully weaned. The cause of septitis remains unidentified. We have found the patient's age and pulmonary hypertension to be closely related to the grade of septitis in this study. Septitis plays a much more important role than pulmonary vascular obstructive change in the prognosis of pulmonary hypertensive heart disease in early infancy.
K Ogawa; H Ito; A Toriyama; T Yamamoto; M Yamaguchi; K Horikoshi; S Asada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  77     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  1979 May 
Date Detail:
Created Date:  1979-06-29     Completed Date:  1979-06-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  728-32     Citation Subset:  AIM; IM    
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MeSH Terms
Ductus Arteriosus, Patent / complications,  pathology
Heart Defects, Congenital / complications,  pathology*
Heart Septal Defects, Ventricular / complications,  pathology
Hypertension, Pulmonary / complications,  pathology*
Infant, Newborn
Lung / pathology*

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