Document Detail

Lung neovascularity in pulmonary arterial hypertension associated with congenital heart defects and idiopathic pulmonary arterial hypertension: study of 198 patients.
MedLine Citation:
PMID:  22205444     Owner:  NLM     Status:  Publisher    
OBJECTIVES: To correlate the severity of lung neovascularity (Sheehan vessels) with the cause and haemodynamic severity of pulmonary arterial hypertension (PAH), pulmonary artery (PA) size and heart disease type in patients with PH associated with congenital heart diseases (PAH-CHD) and idiopathic PH (IPAH). METHODS: We reviewed the HRCT and CT pulmonary angiography studies of 87 patients with PAH-CHD and 111 with IPAH; all had undergone right heart catheterisation. We evaluated the PA size and severity of neovascularity on CT. RESULTS: Neovascularity, which was found in 72% of PAH-CHD (56% with Eisenmenger's syndrome) and in 22% of IPAH patients, is significantly related to the severity of PH and all patients with severe neovascularity had intermediate or high PH. All PAH-CHD patients had a dilated PA with a greater risk of developing severe dilatation (diameter >5 cm). The neovascularity correlated with the PA size only in IPAH. CONCLUSIONS: Neovascularity even if not pathognomonic for PAH-CHD, is significantly more common in these patients, especially in Eisenmenger's syndrome. It is often the first CT sign to indicate the severity of PH in PAH-CHD and IPAH. A neovascularity ≥5 on CT indicates a intermediate or high PH. KEY POINTS: • Large retrospective studying specific lung disorders in patients with pulmonary arterial hypertension. • Neovascularity is often the first CT sign indicating the severity of pulmonary hypertension Alterations of lung parenchyma on CT in pulmonary hypertension are described • The first study to assess the severity of pulmonary hypertension by CT • If substantiated, CT might eventually replace some cardiac catheterisation for evaluating PH.
Cecilia Modolon; Domenico Attinà; Francesco Buia; Fiorella De Luca; Patrizia Fughelli; Maria Letizia Bacchi Reggiani; Massimiliano Palazzini; Alessandra Manes; Enri Leci; Nazzareno Galiè; Maurizio Zompatori
Related Documents :
3622544 - Management of multivalvular heart disease.
15769684 - Robotic aortic valve replacement: case report.
16488724 - Carinal replacement with an aortic allograft.
12181594 - Allograft pulmonary artery root replacement for refractory isolated pulmonic valve endo...
9538314 - Relation of genotype 22q11 deletion to phenotype of pulmonary vessels in tetralogy of f...
17926944 - Femoropopliteal artery centerline interpolation using contralateral shape.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-30
Journal Detail:
Title:  European radiology     Volume:  -     ISSN:  1432-1084     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9114774     Medline TA:  Eur Radiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Cardio-Thoracic-Vascular, Division of Cardio-Thoracic Radiology, Policlinico S.Orsola-Malpighi, via Massarenti 9, 40100, Bologna, Italy,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Changes in functional diversity of soil microbial community with addition of antibiotics sulfamethox...
Next Document:  The role of breast MR imaging in pre-operative determination of invasive disease for ductal carcinom...