| Lung mucociliary transport during high-frequency ventilation. | |
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MedLine Citation:
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PMID: 6751174 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of high-frequency, low-tidal-volume ventilation (HFV) and conventional intermittent positive-pressure ventilation (IPPV) on lung mucociliary transport were compared in 5 anesthetized, intubated mongrel dogs using a radioactive label. An aerosol of [99mTc]sulfur colloid was delivered to the dogs' airways and the subsequent clearance of isotope was followed over 4 h of either HFV or IPPV. After 4 h of IPPV, approximately 8 to 10% of the initial activity had cleared from the lung. By contrast, practically all the isotope remained in the lung after 4 h of HFV. Although the reasons for this were not definitely established in this study, several other observations were made that relate to this question. First, large amounts of mucus were visible in the trachea immediately after each of the 4-h HFV studies, whereas this was so in only one of the IPPV studies. Second, in 5 of 6 studies, a bolus of radioactive label placed on the posterior trachea after 4 h of HFV was noticed to disperse and move rapidly toward distal airways under the influence of HFV. Third, despite these findings of disturbed mucociliary transport during HFV, measurements of tracheal velocity, using a radioactive bolus technique during conventional ventilation, were the same after 4 h of HFV as after 4 h of IPPV (18.4 +/- 2.6 and 15.0 +/- 1.6 mm/min, respectively). We conclude that in the anesthetized dog HFV may alter mucociliary transport. This is unlikely to be the result of major structural damage to the mucosal surface, because tracheal mucous velocity measured after 4 h of HFV was not different from that after IPPV. It may be partly explained, however, by the retrograde flow of mucus that was observed during HFV in 5 of 6 studies. |
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Authors:
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R D McEvoy; N J Davies; G Hedenstierna; M T Hartman; R G Spragg; P D Wagner |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American review of respiratory disease Volume: 126 ISSN: 0003-0805 ISO Abbreviation: Am. Rev. Respir. Dis. Publication Date: 1982 Sep |
Date Detail:
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Created Date: 1982-12-03 Completed Date: 1982-12-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370523 Medline TA: Am Rev Respir Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 452-6 Citation Subset: AIM; IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, General Animals Cilia / physiology* Dogs Lung / physiology* Mucus / physiology* Positive-Pressure Respiration* Respiration, Artificial* Sulfur / diagnostic use Technetium / diagnostic use Technetium Tc 99m Sulfur Colloid Tidal Volume Trachea / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL-17731/HL/NHLBI NIH HHS; HL-23584/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Technetium Tc 99m Sulfur Colloid; 7440-26-8/Technetium; 7704-34-9/Sulfur |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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