| Lung metabolism and systemic organ function. | |
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MedLine Citation:
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PMID: 6749326 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the past decade a variety of metabolic events have been described which occur in the lungs. These processes, such as the clearance of serotonin and norepinephrine, the inactivation of bradykinin and the activation of angiotensin II, and the synthesis of prostaglandins, may have a direct impact on systemic organ function. Under certain circumstances the lungs produce prostaglandins that may lead to severe hemodynamic instability and death. Pressure breathing with hyperinflation is a potent pulmonary metabolic stimulus. This commonly used therapeutic maneuver has been shown to increase fibrinolytic activity. The application of end-expiratory pressure will further enhance the fibrinolytic state by virtue of the pulmonary secretion of plasminogen activator. Positive end-expiratory pressure (PEEP) will also cause a lowering of the cardiac output, which is related at least in part to lung metabolism. Circulating factors are released during PEEP that have a negative inotropic effect. It is reasonable to view respiratory failure not only as a defect in gas exchange but also as a derangement in lung metabolism. |
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Authors:
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H B Hechtman; D Shepro |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Circulatory shock Volume: 9 ISSN: 0092-6213 ISO Abbreviation: Circ. Shock Publication Date: 1982 |
Date Detail:
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Created Date: 1982-12-02 Completed Date: 1982-12-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0414112 Medline TA: Circ Shock Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 457-67 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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metabolism Animals Bradykinin / metabolism Cardiac Output Coronary Circulation Dogs Endothelium / metabolism Fibrinolysis Humans Lung / metabolism*, physiopathology Norepinephrine / metabolism Perfusion Positive-Pressure Respiration Prostaglandins / metabolism Receptors, Serotonin Respiration, Artificial |
| Grant Support | |
ID/Acronym/Agency:
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GM24891/GM/NIGMS NIH HHS; HLB16714/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins; 0/Receptors, Serotonin; 11128-99-7/Angiotensin II; 51-41-2/Norepinephrine; 58-82-2/Bradykinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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