Document Detail


Lung metabolism and systemic organ function.
MedLine Citation:
PMID:  6749326     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the past decade a variety of metabolic events have been described which occur in the lungs. These processes, such as the clearance of serotonin and norepinephrine, the inactivation of bradykinin and the activation of angiotensin II, and the synthesis of prostaglandins, may have a direct impact on systemic organ function. Under certain circumstances the lungs produce prostaglandins that may lead to severe hemodynamic instability and death. Pressure breathing with hyperinflation is a potent pulmonary metabolic stimulus. This commonly used therapeutic maneuver has been shown to increase fibrinolytic activity. The application of end-expiratory pressure will further enhance the fibrinolytic state by virtue of the pulmonary secretion of plasminogen activator. Positive end-expiratory pressure (PEEP) will also cause a lowering of the cardiac output, which is related at least in part to lung metabolism. Circulating factors are released during PEEP that have a negative inotropic effect. It is reasonable to view respiratory failure not only as a defect in gas exchange but also as a derangement in lung metabolism.
Authors:
H B Hechtman; D Shepro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Circulatory shock     Volume:  9     ISSN:  0092-6213     ISO Abbreviation:  Circ. Shock     Publication Date:  1982  
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0414112     Medline TA:  Circ Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  457-67     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Angiotensin II / metabolism
Animals
Bradykinin / metabolism
Cardiac Output
Coronary Circulation
Dogs
Endothelium / metabolism
Fibrinolysis
Humans
Lung / metabolism*,  physiopathology
Norepinephrine / metabolism
Perfusion
Positive-Pressure Respiration
Prostaglandins / metabolism
Receptors, Serotonin
Respiration, Artificial
Grant Support
ID/Acronym/Agency:
GM24891/GM/NIGMS NIH HHS; HLB16714/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Prostaglandins; 0/Receptors, Serotonin; 11128-99-7/Angiotensin II; 51-41-2/Norepinephrine; 58-82-2/Bradykinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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