Document Detail


Lung mechanics, radiography and 67Ga scintigraphy in experimental Pneumocystis carinii pneumonia.
MedLine Citation:
PMID:  3487339     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Respiratory system pressure-volume (P-V) studies, 67Ga-citrate scans, and chest radiographs were made in the corticosteroid-treated rat model of Pneumocystis carinii pneumonia. The steroid treatment used to provoke Pneumocystis infection in this model resulted in a reduction in body weight, lung weight and lung volumes compared to age-matched controls but no change in the normalized pressure-volume curve. P. carinii infection was associated with increased lung wet weight and flattening of the respiratory system P-V curve when compared to either age matched controls or steroid-treated animals on trimethoprim-sulfamethoxazole prophylaxis for P. carinii. Radiographs were interpreted as positive in only three of 11 animals with P. carinii, whereas 10 of 12 animals showed positive gallium-67 lung scans. We conclude that both gallium uptake and altered lung mechanics occur in the rat with Pneumocystis carinii and may reflect increased alveolar permeability and surfactant abnormalities noted in other studies.
Authors:
D C Stokes; W T Hughes; P O Alderson; R E King; D J Garfinkel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of experimental pathology     Volume:  67     ISSN:  0007-1021     ISO Abbreviation:  Br J Exp Pathol     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-08-18     Completed Date:  1986-08-18     Revised Date:  2012-05-07    
Medline Journal Info:
Nlm Unique ID:  0372543     Medline TA:  Br J Exp Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  383-93     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight
Gallium Radioisotopes / diagnostic use
Lung / physiopathology*,  radionuclide imaging
Lung Compliance
Lung Volume Measurements
Male
Organ Size
Pneumonia, Pneumocystis / physiopathology*,  radiography,  radionuclide imaging
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Gallium Radioisotopes
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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