Document Detail

Lung mechanics in hypervolemic pulmonary edema.
MedLine Citation:
PMID:  1141099     Owner:  NLM     Status:  MEDLINE    
Extravascular thermal volume of the lung (ETVL) is a double indicator dilution technique of use in measuring pulmonary edema. ETVL and lung mechanics measurements were followed to find a less invasive monitor of pulmonary edema than the double indicator dilution technique. Pulmonary edema was induced by overloading the dogs' circulation with dextran. Phases of overload were defined on the basis of a previous electron microscopic study (Noble et al., Can. Anesthetists Soc. J. 21:275, 1974) of lung biopsies relating anatomic changes to physiologic measurements of ETVL and central blood volume (CBV). Congestion occurred when CBV was elevated and ETVL was not, interstitial edema when ETVL was elevated but smaller than 60% above control and alveolar edema when ETVL greater than 85% above control. Once the dogs were in alveolar edema, they were mechanically ventilated with 4, 8, 12, and 16 cmH2O end-tidal pressure (CPPV). Mean functional residual capacity (FRC) for all 15 dogs did not change up to the time CPPV was applied. Pulmonary resistance did not rise until alveolar edema was present. Once in pulmonary edema, lung compliance always fell as lung water increased. In individual dogs, the compliance fall was directly proportional to the rising lung water. However, the variations in slope and beginning point among dogs made it difficult to predict the amount of lung water from dynamic compliance values. PaO2 fell markedly in alveolar edema as a result of a widened A-a gradient. CPPV did not decrease lung water but did increase FRC and PaO2.
W H Noble; J C Kay; J Obdrzalek
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied physiology     Volume:  38     ISSN:  0021-8987     ISO Abbreviation:  J Appl Physiol     Publication Date:  1975 Apr 
Date Detail:
Created Date:  1975-09-24     Completed Date:  1975-09-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376576     Medline TA:  J Appl Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  681-7     Citation Subset:  IM; S    
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MeSH Terms
Blood Volume
Body Water / analysis
Cardiac Output
Lung / analysis,  physiopathology*
Lung Compliance
Pulmonary Edema / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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