Document Detail


Lung mechanics during induced bronchoconstriction.
MedLine Citation:
PMID:  8872669     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To elucidate differences in lung mechanics, we investigated the relative changes of partial forced expiratory flows at 50 and 30% of vital capacity, pulmonary resistance (RL), dynamic elastance (Edyn), and the effects of a deep inhalation (DI) on maximal flows, Edyn, and RL in eight asthmatic and eight normal individuals during bronchial challenges with methacholine, histamine, and ATP. RL was partitioned into inspiratory and expiratory resistance. Different constrictor agents did not induce specific patterns of response. For a given decrement of flow at 50 and 30% vital capacity, RL increased significantly more in normal than in asthmatic individuals. The ratio of inspiratory to expiratory RL was always < 1 at baseline but became > 1 in the majority of asthmatic and normal individuals when RL exceeded 12.2 +/- 0.9 cmH2O.1-1.s, suggesting that tidal inspiration may have induced transient bronchodilation in more constricted subjects. In asthmatic individuals, DI had a significantly smaller effect on flow but not on RL compared with normal individuals. The recovery of RL and Edyn after DI was faster than Edyn for both normal and asthmatic individuals. These findings are consistent with the idea that asthmatic individuals have a stronger peripheral response to agonists than normal individuals.
Authors:
R Pellegrino; O Wilson; G Jenouri; J R Rodarte
Related Documents :
2965139 - Prevention of exercise-induced bronchospasm in asthmatic children. effect of aerosol an...
3204249 - The effects of nalmefene, a potent oral opiate antagonist, on exercise-induced bronchos...
21404069 - Cardiac β-adrenergic responsiveness with exercise.
16024529 - Gas exchange during exercise in habitually active asthmatic subjects.
1778919 - Regional deposition of 3.6-micron particles and lung function in asthmatic subjects.
12232449 - High-resolution computed tomography findings are correlated with disease severity in as...
18027309 - Caffeine consumption amongst british athletes following changes to the 2004 wada prohib...
16283369 - Adaptation of left ventricular morphology to long-term training in sprint- and enduranc...
23236449 - Transient increase in homocysteine but not hyperhomocysteinemia during acute exercise a...
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  81     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1997-01-23     Completed Date:  1997-01-23     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  964-75     Citation Subset:  IM    
Affiliation:
Pulmonary Section, Baylor College of Medicine, Houston, Texas 77030, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / pharmacology
Adult
Airway Resistance / drug effects,  physiology
Asthma / physiopathology*
Bronchoconstriction / drug effects,  physiology*
Bronchoconstrictor Agents / pharmacology*
Constriction, Pathologic / physiopathology
Female
Forced Expiratory Volume
Histamine / pharmacology
Humans
Lung / drug effects,  physiology*
Male
Methacholine Chloride / pharmacology
Respiratory Mechanics / drug effects,  physiology*
Smoking / adverse effects
Spirometry
Tidal Volume / physiology
Total Lung Capacity / physiology
Grant Support
ID/Acronym/Agency:
HL-46230/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Bronchoconstrictor Agents; 51-45-6/Histamine; 56-65-5/Adenosine Triphosphate; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Multiple-breath washout and washin experiments in steers.
Next Document:  Circulatory sequelae of administering CPAP in hyperdynamic sepsis are time dependent.