Document Detail

Lung mechanics during induced bronchoconstriction.
MedLine Citation:
PMID:  8872669     Owner:  NLM     Status:  MEDLINE    
To elucidate differences in lung mechanics, we investigated the relative changes of partial forced expiratory flows at 50 and 30% of vital capacity, pulmonary resistance (RL), dynamic elastance (Edyn), and the effects of a deep inhalation (DI) on maximal flows, Edyn, and RL in eight asthmatic and eight normal individuals during bronchial challenges with methacholine, histamine, and ATP. RL was partitioned into inspiratory and expiratory resistance. Different constrictor agents did not induce specific patterns of response. For a given decrement of flow at 50 and 30% vital capacity, RL increased significantly more in normal than in asthmatic individuals. The ratio of inspiratory to expiratory RL was always < 1 at baseline but became > 1 in the majority of asthmatic and normal individuals when RL exceeded 12.2 +/- 0.9 cmH2O.1-1.s, suggesting that tidal inspiration may have induced transient bronchodilation in more constricted subjects. In asthmatic individuals, DI had a significantly smaller effect on flow but not on RL compared with normal individuals. The recovery of RL and Edyn after DI was faster than Edyn for both normal and asthmatic individuals. These findings are consistent with the idea that asthmatic individuals have a stronger peripheral response to agonists than normal individuals.
R Pellegrino; O Wilson; G Jenouri; J R Rodarte
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  81     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1997-01-23     Completed Date:  1997-01-23     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  964-75     Citation Subset:  IM    
Pulmonary Section, Baylor College of Medicine, Houston, Texas 77030, USA.
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MeSH Terms
Adenosine Triphosphate / pharmacology
Airway Resistance / drug effects,  physiology
Asthma / physiopathology*
Bronchoconstriction / drug effects,  physiology*
Bronchoconstrictor Agents / pharmacology*
Constriction, Pathologic / physiopathology
Forced Expiratory Volume
Histamine / pharmacology
Lung / drug effects,  physiology*
Methacholine Chloride / pharmacology
Respiratory Mechanics / drug effects,  physiology*
Smoking / adverse effects
Tidal Volume / physiology
Total Lung Capacity / physiology
Grant Support
Reg. No./Substance:
0/Bronchoconstrictor Agents; 51-45-6/Histamine; 56-65-5/Adenosine Triphosphate; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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