| Lung mast cells and hypoxic pulmonary hypertension. | |
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MedLine Citation:
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PMID: 22188111 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Hypoxic pulmonary hypertension (HPH) is a syndrome characterized by the increase of pulmonary vascular tone and the structural remodeling of peripheral pulmonary arteries. Mast cells have an important role in many inflammatory diseases and they are also involved in tissue remodeling. Tissue hypoxia is associated with mast cell activation and the release of proteolytic enzymes, angiogenic and growth factors which mediate tissue destruction and remodeling in a variety of physiological and pathological conditions. Here we focused on the role of mast cells in the pathogenesis of hypoxic pulmonary hypertension from the past to the present. |
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Authors:
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H Maxová; J Herget; M Vízek |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-20 |
Journal Detail:
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Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: - ISSN: 1802-9973 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Pathophysiology, Second Faculty of Medicine, Charles University in Prague, Prague, Czech Republic. hana.maxova@lfmotol.cuni.cz. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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