Document Detail

Lung lymph flow after bone marrow injection into goats was reduced by indomethacin.
MedLine Citation:
PMID:  3549677     Owner:  NLM     Status:  MEDLINE    
We examined the pulmonary response to bone marrow embolism in untreated and indomethacin-treated goats. Pulmonary arterial pressure increased by 15 cmH2O after bone marrow infusion, reaching a peak of 37.2 then stabilizing at greater than 30 cmH2O in the control group. In the treated group it increased by 4.3 cmH2O from a base line of 18.5 cmH2O but had returned to base line by 6 h. Lymph flow increased in the control group from a base line of 7.3 ml/h to a peak of 22.4 ml/h and remained near that level. It increased from a base line of 6.4 ml/h to a peak of 9.8 ml/h in the treated group and remained close to that value. The lymph-to-plasma protein ratio was little changed throughout the experiment. Cardiac output decreased by 1.2 l/min in the control group but was unchanged from base line in the treated group. Systemic arterial pressure was similar in both groups of animals. We conclude that indomethacin prevents the pulmonary hypertension seen after bone marrow infusion and protects against some of the increased permeability.
R Winn; R Maunder; J Harlan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  62     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-05-18     Completed Date:  1987-05-18     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  762-7     Citation Subset:  IM    
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MeSH Terms
Blood Proteins / metabolism
Bone Marrow Transplantation*
Cardiac Output
Epoprostenol / blood
Indomethacin / pharmacology*
Lung / drug effects,  metabolism*,  physiology
Lymph / drug effects,  metabolism*
Osmolar Concentration
Oxygen / blood
Partial Pressure
Thromboxane A2 / blood
Grant Support
Reg. No./Substance:
0/Blood Proteins; 35121-78-9/Epoprostenol; 53-86-1/Indomethacin; 57576-52-0/Thromboxane A2; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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